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22715 Hepatitis C Antibody

Hepatitis C Antibody
Test Code: HCVAB
Synonyms/Keywords
Anti-HCV, HCVAB, Anti-Hepatitis C Virus, Hepatitis C Antibody-EIA​
Useful For
To aid in the diagnosis of ongoing or past hepatitis C infection.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​Serum Separator Tube (SST)Red Top Tube (RTT)​0.5 mL​0.4 mL​0.3 mL​
Collection Processing Instructions
Separate serum from the blood within 60 minutes of venipuncture and transport in an aliquot tube. Specimen must be free of particulate matter including fibrin. 

Regional/Outreach sites: Please send samples to Marshfield frozen.

High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay. It is recommended that patients refrain from consuming any multivitamin or supplement containing biotin for at least 72 hours prior to collection of a blood sample.
Specimen Stability Information
Specimen Type Temperature Time
​​
Serum​ ​		​Ambient
​​<8 hours
​Refrigerate
 <48 hours
Frozen​ at -20 °C  6 months
​Frozen at -70 °C >6 months
Rejection Criteria
​Grossly hemolyzed
​Grossly icteric
​Specimens containing precipitate
​Cadaver specimens
​Heat-inactivated specimens
​Body fluids other than serum
Interference
Heterophilic antibodies in human serum can react with the immunoglobulins included in the assay components causing interference with immunoassay.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Sandwich Chemiluminometric Immunoassay/Siemens Centaur
Test Information

Hepatitis C is a viral infection primarily of the liver. Upon initial infection patients may develop an acute hepatitis syndrome of varying severity, or remain symptom-free. Chronic infections follow in 50-80% of all cases. Chronic hepatitis C remains latent for years or decades before reemerging to cause cirrhosis or liver cancer.

Limitations:
• A negative test result does not exclude the possibility of exposure to hepatitis C virus.
• The calculated values for hepatitis C in a given specimen as determined by assays from different manufacturers can vary due to differences in assay methods and reagent specificity. Values obtained with different assay methods cannot be used interchangeably.
• The performance of the assay has not been established for populations of immunocompromised, immunosuppressed, neonatal specimens, infants, children, or adolescent patients and cadaver specimens.
• A reactive anti-HCV result does not exclude co-infection by another hepatitis virus.

Reference Range Information
Performing Location Reference Range
Marshfield​ Reported as "Reactive" or "Non-reactive" or "Equivocal".
Reactive results will include comment on signal to cutoff' ratio.​
Interpretation
A Reactive result indicates the presence of anti-hepatitis C virus total antibodies; it does not distinguish between phases of infection, or whether the infection is ongoing or historical. The Hepatitis C Virus RNA, Quantitative test (test code HCVQT) may be used to detect ongoing viral replication
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86803   ​ ​ ​ ​ ​
Synonyms/Keywords
Anti-HCV, HCVAB, Anti-Hepatitis C Virus, Hepatitis C Antibody-EIA​
Ordering Applications
Ordering Application Description
​Centricity

​a. Hepatitis C Ab

b. Hep. C Virus Ab (HCVAB)

​Cerner ​Hepatitis C Antibody, Total
​Clinical Order Manager ​Hepatitis C virus Ab-EIA
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Serum​Serum Separator Tube (SST)Red Top Tube (RTT)​0.5 mL​0.4 mL​0.3 mL​
Collection Processing
Separate serum from the blood within 60 minutes of venipuncture and transport in an aliquot tube. Specimen must be free of particulate matter including fibrin. 

Regional/Outreach sites: Please send samples to Marshfield frozen.

High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay. It is recommended that patients refrain from consuming any multivitamin or supplement containing biotin for at least 72 hours prior to collection of a blood sample.
Specimen Stability Information
Specimen Type Temperature Time
​​
Serum​ ​		​Ambient
​​<8 hours
​Refrigerate
 <48 hours
Frozen​ at -20 °C  6 months
​Frozen at -70 °C >6 months
Rejection Criteria
​Grossly hemolyzed
​Grossly icteric
​Specimens containing precipitate
​Cadaver specimens
​Heat-inactivated specimens
​Body fluids other than serum
Interference
Heterophilic antibodies in human serum can react with the immunoglobulins included in the assay components causing interference with immunoassay.
Useful For
To aid in the diagnosis of ongoing or past hepatitis C infection.
Reference Range Information
Performing Location Reference Range
Marshfield​ Reported as "Reactive" or "Non-reactive" or "Equivocal".
Reactive results will include comment on signal to cutoff' ratio.​
Interpretation
A Reactive result indicates the presence of anti-hepatitis C virus total antibodies; it does not distinguish between phases of infection, or whether the infection is ongoing or historical. The Hepatitis C Virus RNA, Quantitative test (test code HCVQT) may be used to detect ongoing viral replication
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Sandwich Chemiluminometric Immunoassay/Siemens Centaur
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86803   ​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.