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22708 Hepatitis B Core Antibody, IgM

Hepatitis B Core Antibody, IgM
Test Code: ABC-M
Synonyms/Keywords
Anti-HBc (IgM), Anti-HB Core (IgM)​
Useful For
To aid in the diagnosis of hepatitis B and determining the phase of a hepatitis B infection.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Serum​Serum Separator Tube (SST)​Red Top Tube (RTT)​1 mL​0.5 mL​0.3 mL​
Collection Processing Instructions
Separate serum from the blood within 60 minutes of venipuncture and transport in an aliquot tube. Specimen must be free of particulate matter including fibrin. Store samples at 2 to 8°C if not tested within 8 hours of collection. The frozen specimens should be completely thawed, thoroughly mixed and centrifuged before analysis.
 
High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay. It is recommended that patients refrain from consuming any multivitamin or supplement containing biotin for at least 72 hours prior to collection of a blood sample.
Specimen Stability Information
Specimen Type Temperature Time
Serum ​ Ambient​ < 8 hours​
Refrigerated​ 2 days​
Frozen​ at -20 °C 6 months​
​Frozen at -70 °C ​>6 months
Rejection Criteria
​Grossly hemolyzed
​Grossly icteric
​Specimens containing precipitate
​Cadaver specimens
Heat-inactivated specimens​
​Body fluids other than serum
Interference
Heterophilic antibodies in human serum can react with the immunoglobulins included in the assay components causing interference with immunoassay.
 
High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Immunocapture Chemiluminometric Immunoassay/Siemens Centaur 
Test Information

Hepatitis B is a viral illness that is transmitted through blood and other body fluids. Both acute and chronic stages occur, with the frequency of progression to chronicity declining with age at time of infection. Chronic hepatitis B often leads to cirrhosis and hepatocellular carcinoma. Hepatitis B is a vaccine-preventable disease.

Limitations
• The results determined by different assays from different manufacturers can vary due to differences in assay specificities and cannot be used interchangeably.
• The performance of the assay has not been established with cord blood, neonatal specimens, immunocompromised, immunosuppressed, cadaver specimens.
• A reactive Anti-Hepatitis B core IgM result does not exclude co-infection by another hepatitis virus.

Reference Range Information
Performing Location Reference Range
Marshfield​

Reported as "Reactive" or "Non-reactive" or "Equivocal".

Interpretation
The presence of hepatitis B core IgM antibody is consistent with an acute hepatitis B infection. A result of a single hepatitis B lab study should be interpreted with caution.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
86705​
Synonyms/Keywords
Anti-HBc (IgM), Anti-HB Core (IgM)​
Ordering Applications
Ordering Application Description
​Centricity ​Hep. B Core Ab IgM (Anti-HBc)
​Cerner ​Hepatitis B Core Antibody, IgM
​Clinical Order Manager ​Hepatitis B Core Ab-IgM
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Serum​Serum Separator Tube (SST)​Red Top Tube (RTT)​1 mL​0.5 mL​0.3 mL​
Collection Processing
Separate serum from the blood within 60 minutes of venipuncture and transport in an aliquot tube. Specimen must be free of particulate matter including fibrin. Store samples at 2 to 8°C if not tested within 8 hours of collection. The frozen specimens should be completely thawed, thoroughly mixed and centrifuged before analysis.
 
High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay. It is recommended that patients refrain from consuming any multivitamin or supplement containing biotin for at least 72 hours prior to collection of a blood sample.
Specimen Stability Information
Specimen Type Temperature Time
Serum ​ Ambient​ < 8 hours​
Refrigerated​ 2 days​
Frozen​ at -20 °C 6 months​
​Frozen at -70 °C ​>6 months
Rejection Criteria
​Grossly hemolyzed
​Grossly icteric
​Specimens containing precipitate
​Cadaver specimens
Heat-inactivated specimens​
​Body fluids other than serum
Interference
Heterophilic antibodies in human serum can react with the immunoglobulins included in the assay components causing interference with immunoassay.
 
High doses of exogenous biotin (also termed Vitamin B7, Vitamin H or Coenzyme R) may interfere with this assay.
Useful For
To aid in the diagnosis of hepatitis B and determining the phase of a hepatitis B infection.
Reference Range Information
Performing Location Reference Range
Marshfield​

Reported as "Reactive" or "Non-reactive" or "Equivocal".

Interpretation
The presence of hepatitis B core IgM antibody is consistent with an acute hepatitis B infection. A result of a single hepatitis B lab study should be interpreted with caution.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Immunocapture Chemiluminometric Immunoassay/Siemens Centaur 
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
86705​
For most current information refer to the Marshfield Laboratory online reference manual.