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22684 Lysozyme, Plasma (MURA)

Lysozyme, Plasma (MURA)
Test Code: MISC
Synonyms/Keywords
​Muramidase
Useful For

As a screening test for ocular sarcoidosis.

Confirming marked increases in the granulocyte or monocyte pools as in granulocytic or monocytic leukemias, myeloproliferative disorders, and malignant histiocytosis

 
Following the course of therapy in cases of chronic granulocytic or chronic monocytic leukemias
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Plasma EDTA Lavender Top Tube (LTT)​ 2 mL​ 1 mL​
Collection Processing Instructions

​1.  Centrifuge and transfer plasma to a plastic vial within 2 hours of collection.

2.  Freeze immediately after transferring. 

Specimen Stability Information
Specimen Type Temperature Time
​Plasma Frozen​ ​21 days
Rejection Criteria

​All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Interference

​Increased levels may be seen in nonmalignant disorders including sarcoidosis, infections, Crohn's disease, kidney transplant rejection, and other renal disorders.

Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories
Monday through Friday​
2-5 days​
Turbidimetric​
Reference Lab
Test Information

​Lysozyme is a bacteriolytic enzyme that is found in some hematopoietic cells. It is primarily present in granulocytes, monocytes, and histiocytes. The enzyme is present in only minute amounts in lymphocytes; and is not present in myeloblasts, eosinophils, and basophils. 

Lysozyme in the plasma comes chiefly from the degradation of granulocytes and monocytes and its concentration reflects the turnover of these cells. Increases are seen in benign (eg, infection, inflammation) and malignant processes (eg, some leukemias). Plasma lysozyme is elevated in patients with acute or chronic granulocytic or monocytic leukemias and falls with successful treatment. Conversely, patients with lymphocytic leukemia may have depressed plasma lysozyme levels.

Patients with renal disorders (including rejection of transplanted kidneys) or Crohn disease (regional enteritis) also tend to have elevated levels of plasma lysozyme.

Reference Range Information
> or = 12 months:  2.6-6.0 mcg/mL
Reference values have not been established for patients who are < 12 months of age.
Interpretation
​Levels >200 mcg/mL may be seen in acute nonlymphocytic leukemia (M2, M4, M5) or chronic granulocytic leukemias.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​85549
Synonyms/Keywords
​Muramidase
Ordering Applications
Ordering Application Description
​Centricity ​Lysozyme (MURA)
​Cerner ​Lysozyme (MURA)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Plasma EDTA Lavender Top Tube (LTT)​ 2 mL​ 1 mL​
Collection Processing

​1.  Centrifuge and transfer plasma to a plastic vial within 2 hours of collection.

2.  Freeze immediately after transferring. 

Specimen Stability Information
Specimen Type Temperature Time
​Plasma Frozen​ ​21 days
Rejection Criteria

​All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Interference

​Increased levels may be seen in nonmalignant disorders including sarcoidosis, infections, Crohn's disease, kidney transplant rejection, and other renal disorders.

Useful For

As a screening test for ocular sarcoidosis.

Confirming marked increases in the granulocyte or monocyte pools as in granulocytic or monocytic leukemias, myeloproliferative disorders, and malignant histiocytosis

 
Following the course of therapy in cases of chronic granulocytic or chronic monocytic leukemias
Reference Range Information
> or = 12 months:  2.6-6.0 mcg/mL
Reference values have not been established for patients who are < 12 months of age.
Interpretation
​Levels >200 mcg/mL may be seen in acute nonlymphocytic leukemia (M2, M4, M5) or chronic granulocytic leukemias.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories
Monday through Friday​
2-5 days​
Turbidimetric​
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​85549
For most current information refer to the Marshfield Laboratory online reference manual.