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22647 Fructosamine, Serum (FRUCT)

Fructosamine, Serum (FRUCT)
Test Code: FRUTSO
Synonyms/Keywords
Glycated Protein, Protein Bound Glucose
Useful For
​Assessing intermediate-term glycemic control
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Serum Serum Separator Tube (SST)​ Red Top Tube (RTT)​ 1.0 mL​ 0.25 mL​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ ​ Refrigerated (preferred)​ 7 days​
Frozen ​ 7 days​
Ambient ​ 72 hours​
Rejection Criteria
Gross hemolysis
​Gross icterus
Interference

​Since the assay is nonspecific, color may be generated by compounds other than glycated proteins. Interferences are seen from ascorbic acid (vitamin C) and elevated bilirubin values.

However, the second-generation assays have been shown to be highly specific for glycated proteins.

Fasting blood glucose and hemoglobin A1c are the usual and preferred means of monitoring glycemic control.

Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories
Monday through Sunday​
1-2 day​s
Colorimetric Rate Reaction​
Reference Lab
Test Information

​Fructosamine is a general term, which applies to any glycated protein. It is formed by the nonenzymatic reaction of glucose with the a- and e-amino groups of proteins to form intermediate compounds called aldimines. These aldimines may dissociate or undergo an Amadori rearrangement to form stable ketoamines called fructosamines. This nonenzymatic glycation of specific proteins in vivo is proportional to the prevailing glucose concentration during the lifetime of the protein. Therefore, glycated protein measurement in the diabetic patient is felt to be a better monitor of long-term glycemic control than individual or sporadic glucose determinations. The best known of these proteins is glycated hemoglobin which is often measured as hemoglobin A1c, and reflects glycemic control over the past 6 to 8 weeks. In recognition of the need for a measurement that reflects intermediate-term glycemic control and was easily automated, a nonspecific test, termed fructosamine, was developed. Since albumin is the most abundant serum protein, it accounts for 80% of the glycated serum proteins, and thus, a high proportion of the fructosamine. Although a large portion of the color generated in the reaction is contributed by glycated albumin, the method will measure all proteins, each with a different half-life and different levels of glycation.

Reference Range Information
200-285 mcmol/L
Interpretation
​In general, fructosamine reflect glycemic control in diabetic patients over the previous 2 to 3 weeks. High values indicate poor control.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​82985
Synonyms/Keywords
Glycated Protein, Protein Bound Glucose
Ordering Applications
Ordering Application Description
​COM ​Fructosamine (FRUCT)
​Cerner Fructosamine, Serum (FRUCT)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Serum Serum Separator Tube (SST)​ Red Top Tube (RTT)​ 1.0 mL​ 0.25 mL​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ ​ Refrigerated (preferred)​ 7 days​
Frozen ​ 7 days​
Ambient ​ 72 hours​
Rejection Criteria
Gross hemolysis
​Gross icterus
Interference

​Since the assay is nonspecific, color may be generated by compounds other than glycated proteins. Interferences are seen from ascorbic acid (vitamin C) and elevated bilirubin values.

However, the second-generation assays have been shown to be highly specific for glycated proteins.

Fasting blood glucose and hemoglobin A1c are the usual and preferred means of monitoring glycemic control.

Useful For
​Assessing intermediate-term glycemic control
Reference Range Information
200-285 mcmol/L
Interpretation
​In general, fructosamine reflect glycemic control in diabetic patients over the previous 2 to 3 weeks. High values indicate poor control.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories
Monday through Sunday​
1-2 day​s
Colorimetric Rate Reaction​
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​82985
For most current information refer to the Marshfield Laboratory online reference manual.