Monitoring of control of diabetes mellitus.
Monitoring the effects of therapeutic diet/exercise lifestyle changes
Patients receiving therapeutic heparin are unsuitable for this analysis. Heparin causes the release of free fatty acids by stimulating the activity of lipoprotein lipase, which causes triglycerides associated with blood lipoproteins to release free fatty acids.
In order to eliminate the generation of free fatty acids from triglycerides by serum lipases (causing erroneous elevations), serum should be frozen as soon as possible after it is collected and shipped frozen.
Elevated serum concentrations of nonesterified fatty acids (NEFA) are associated with cardiovascular disease, metabolic syndrome, obesity, and type 2 diabetes mellitus. NEFA are causally linked with insulin resistance and inflammation of vascular endothelium.
> or =18 years: 0.00-0.72 mmol/L
Reference values have not been established for patients who are <18 years of age.