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22483 Creatinine

Creatinine
Test Code: CREAT
Synonyms/Keywords
i-Stat Creatinine
Useful For
Creatinine measurements are used in the diagnosis and treatment of renal diseases, in monitoring renal dialysis, and as a calculation basis for measuring other urine analytes.​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ ​ Plasma​/Serum Lithium-heparin Plasma Separator (PST)​, Serum Separator Tube (SST) Lithium or Sodium-heparin Green Top (GTT), Red Top Tube(RTT) 1 mL​ 0.3 mL​ 0.5 mL whole blood​
​i-Stat only = Whole Blood ​Lithium-heparin Green Top Tube (GTT) ​1 mL ​200 uL
Collection Processing Instructions

Samples collected in a GTT or RTT must be removed from cells within one hour for storage or transport. Samples collected in gel barrier tubes must be removed from the primary tube prior to transporting to Marshfield. Do not send the primary collection tube.

Stat orders will be run locally on the i-Stat.  Non-stat orders will be sent to Marshfield for analysis.

i-Stat:  Sample must be tested within 10 minutes of collection.

Specimen Stability Information
Specimen Type Temperature Time
Plasma/Serum​ ​ ​ Ambient​ 7 days
Refrigerate​ 7 days​
Frozen​ 2 months
​i-Stat Whole Blood ​Ambient ​10 minutes
Rejection Criteria
​i-Stat testing:  clotted samples
​i-Stat testing:  anticoagulants other than lithium heparin
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Bloomer ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
Modified Jaffe Kinetic Fixed Assay/Beckman AU
​​Amperometrical-Enzymatic/i-Stat
​Cadott ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Chetek ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Chippewa Falls ​​Monday through Friday ​Less than 2 hours​ ​Modified Jaffe Reaction/Siemens Dimension
​Colby/Abbotsford ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Cornell ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Cumberland ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Diagnostic Treatment Center ​Monday through Sunday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Eagle River ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Eau Claire ​Monday through Sunday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Flambeau Hospital ​Monday through Sunday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Hayward ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Ladysmith Medical Center ​​Monday through Sunday ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Lake Hallie ​Monday through Sunday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Lakeview Medical Center ​Monday through Sunday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
Marshfield​ Monday through Sunday​ Less than 2 hours​ Modified Jaffe Kinetic Fixed Assay/Beckman AU​
​Mercer ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Merrill Monday through Saturday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Minocqua ​Monday through Sunday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Mosinee ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Neillsville​​Monday through Sunday​Less than 2 hours​​Modified Jaffe Reaction/Siemens Dimension​
​Oakwood ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Phillips ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Rhinelander ​Monday through Friday 1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours​​
Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat​
Stettin​ ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Stevens Point ​​Monday through Friday ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Wausau ​Monday through Sunday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
Wisconsin Rapids​ ​​Monday through Friday ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Wittenberg ​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours 
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
Test Information

Estimated glomerular filtration rate in mL/min/1.73m² is based on age, gender, and creatinine for patients in age range from 18-80 years. Formula assumes Caucasian ethnicity. For Afro-Americans, manually multiply result by 1.21.
Formula used is the Simplified MDRD (Modification of Diet in Renal Disease) 4 parameter IDMS equation for Adults, recommended by the NKDEP. GFR = 175 x (creat^ -1.154) x (Age ^ -0.203) x 0.742 (if female)

Hydroxyurea (Hydrea®, Droxia®) may cause significant errors in the measurement of creatinine with the i-STAT System. For every 100 µmol/L hydroxyurea in the whole blood sample, creatinine will be increased by approximately 1.85 mg/dL. Recommended to use an alternative method (e.g the modified jaffe reaction in the main laboratory) to measure creatinine in patients on hydroxyurea.

Reference Range Information
Performing Location Reference Range
All Performing Sites other than i-Stat testing             0 - 3 yrs.:    0.3 - 0.6 mg/dL
          4 - 13 yrs.:    0.4 - 0.8 mg/dL 
    Male >=14 yrs.:   0.6 - 1.2 mg/dL
Female >=14 yrs.:   0.4 - 1.0 mg/dL
Calculated GFR (eGFR): >60 mL/min​
​i-Stat testing

0 - 3 yrs.: 0.3 - 0.6 mg/dL
4 - 13 yrs.: 0.4 - 0.8 mg/dL
​Male >=14 yrs.: 0.6 - 1.3 mg/dL
Female >=14 yrs.: 0.5 - 1.1 mg/dL
Calculated GFR (eGFR): >60 mL/min​

See Critical Value Policy for list of current critical values.​​ ​
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
82565 ​
Synonyms/Keywords
i-Stat Creatinine
Ordering Applications
Ordering Application Description
​Centricity ​Creatinine-Blood
​Cerner ​Creatinine
​COM ​Creatinine - Blood
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ ​ Plasma​/Serum Lithium-heparin Plasma Separator (PST)​, Serum Separator Tube (SST) Lithium or Sodium-heparin Green Top (GTT), Red Top Tube(RTT) 1 mL​ 0.3 mL​ 0.5 mL whole blood​
​i-Stat only = Whole Blood ​Lithium-heparin Green Top Tube (GTT) ​1 mL ​200 uL
Collection Processing

Samples collected in a GTT or RTT must be removed from cells within one hour for storage or transport. Samples collected in gel barrier tubes must be removed from the primary tube prior to transporting to Marshfield. Do not send the primary collection tube.

Stat orders will be run locally on the i-Stat.  Non-stat orders will be sent to Marshfield for analysis.

i-Stat:  Sample must be tested within 10 minutes of collection.

Specimen Stability Information
Specimen Type Temperature Time
Plasma/Serum​ ​ ​ Ambient​ 7 days
Refrigerate​ 7 days​
Frozen​ 2 months
​i-Stat Whole Blood ​Ambient ​10 minutes
Rejection Criteria
​i-Stat testing:  clotted samples
​i-Stat testing:  anticoagulants other than lithium heparin
Useful For
Creatinine measurements are used in the diagnosis and treatment of renal diseases, in monitoring renal dialysis, and as a calculation basis for measuring other urine analytes.​
Reference Range Information
Performing Location Reference Range
All Performing Sites other than i-Stat testing             0 - 3 yrs.:    0.3 - 0.6 mg/dL
          4 - 13 yrs.:    0.4 - 0.8 mg/dL 
    Male >=14 yrs.:   0.6 - 1.2 mg/dL
Female >=14 yrs.:   0.4 - 1.0 mg/dL
Calculated GFR (eGFR): >60 mL/min​
​i-Stat testing

0 - 3 yrs.: 0.3 - 0.6 mg/dL
4 - 13 yrs.: 0.4 - 0.8 mg/dL
​Male >=14 yrs.: 0.6 - 1.3 mg/dL
Female >=14 yrs.: 0.5 - 1.1 mg/dL
Calculated GFR (eGFR): >60 mL/min​

See Critical Value Policy for list of current critical values.​​ ​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Bloomer ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
Modified Jaffe Kinetic Fixed Assay/Beckman AU
​​Amperometrical-Enzymatic/i-Stat
​Cadott ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Chetek ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Chippewa Falls ​​Monday through Friday ​Less than 2 hours​ ​Modified Jaffe Reaction/Siemens Dimension
​Colby/Abbotsford ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Cornell ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Cumberland ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Diagnostic Treatment Center ​Monday through Sunday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Eagle River ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Eau Claire ​Monday through Sunday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Flambeau Hospital ​Monday through Sunday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Hayward ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Ladysmith Medical Center ​​Monday through Sunday ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Lake Hallie ​Monday through Sunday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Lakeview Medical Center ​Monday through Sunday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
Marshfield​ Monday through Sunday​ Less than 2 hours​ Modified Jaffe Kinetic Fixed Assay/Beckman AU​
​Mercer ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Merrill Monday through Saturday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Minocqua ​Monday through Sunday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Mosinee ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Neillsville​​Monday through Sunday​Less than 2 hours​​Modified Jaffe Reaction/Siemens Dimension​
​Oakwood ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Phillips ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Rhinelander ​Monday through Friday 1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours​​
Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat​
Stettin​ ​​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
​Stevens Point ​​Monday through Friday ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Wausau ​Monday through Sunday​ ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
Wisconsin Rapids​ ​​Monday through Friday ​Less than 2 hours​ ​​Modified Jaffe Reaction/Siemens Dimension
​Wittenberg ​Monday through Friday
1 day (sent to Marshfield)
* stat order on i-Stat run locally = Less than 2 hours 
​​Modified Jaffe Kinetic Fixed Assay/Beckman AU
​Amperometrical-Enzymatic/i-Stat
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
82565 ​
For most current information refer to the Marshfield Laboratory online reference manual.