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22480 Creatine Kinase, Total

Creatine Kinase, Total
Test Code: CK
Synonyms/Keywords
CK, C. Kinase, CPK​
Useful For
Creatine kinase (CK) is widely distributed in the tissues of the body, with greatest activity in skeletal muscle, heart muscle and the brain.  Any damage to these tissues will result in increased excretion of CK into the blood stream.  Some conditions that contribute to increased CK include Duchenne-type muscular dystrophy, myocardial infarction, central nervous system disorders, hypothyroidism, Reye’s syndrome and other muscle trauma (surgery, injuries, severe exercise).  ​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No Plasma​/Serum Lithium-heparin Plasma Separator (PST)​, Serum Separator Tube (SST) Lithium or Sodium-heparin Green Top (GTT), Red Top Tube (RTT)
 1 mL​ 0.5 mL​ ​
Specimen Stability Information
Specimen Type Temperature Time
Plasma​/Serum ​ ​ Ambient​ 5 days​
Refrigerate​ 7 days​
Frozen​ 3 months​
Rejection Criteria
Samples collected with potassium oxalate, sodium citrate or sodium fluoride preservatives.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Diagnostic Treatment Center​ ​Monday through Sunday​​​ ​Less than 2 hours​ ​Coupled Enzyme Reaction/Siemens Dimension
​Eau Claire ​Monday through Sunday​​​ ​Less than 2 hours​ ​​Coupled Enzyme Reaction/Siemens Dimension
​Flambeau Hospital ​Monday through Sunday​​​ ​Less than 2 hours​ ​​Coupled Enzyme Reaction/Siemens Dimension
​Ladysmith Medical Center ​Monday through Sunday ​Less than 2 hours​ ​​Coupled Enzyme Reaction/Siemens Dimension
​Lakeview Medical Center ​Monday through Sunday​​​ ​Less than 2 hours​ ​​Coupled Enzyme Reaction/Siemens Dimension
Marshfield​ Monday through Sunday​​​ Less than 2 hours​ IFCC-CK (NAC) Rate Assay/Beckman AU
​Minocqua ​Monday through Sunday​​​ ​Less than 2 hours​ ​​Coupled Enzyme Reaction/Siemens Dimension
​Neillsville​Monday through Sunday​Less than 2 hours​Coupled Enzyme Reaction/Siemens Dimension
​Wausau ​Monday through Sunday​​​ ​Less than 2 hours​ ​​Coupled Enzyme Reaction/Siemens Dimension
Test Information
Outpatient CK reference ranges vary considerably with physical activity and range up to 320 U/L for males and 230 U/L for females.​
Reference Range Information
Performing Location Reference Range
All Performing Sites using Dimension Male: 50-235 IU/L
Female: 36-170 IU/L​
​Marshfield ​Male: 46-217 U/L
Female: 33-157 U/L​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82550 ​ ​ ​ ​ ​
Synonyms/Keywords
CK, C. Kinase, CPK​
Ordering Applications
Ordering Application Description
​Centricity

​a. CK (Creatine Kinase)

b. Creatine Kinase

​Cerner ​Creatine Kinase
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No Plasma​/Serum Lithium-heparin Plasma Separator (PST)​, Serum Separator Tube (SST) Lithium or Sodium-heparin Green Top (GTT), Red Top Tube (RTT)
 1 mL​ 0.5 mL​ ​
Specimen Stability Information
Specimen Type Temperature Time
Plasma​/Serum ​ ​ Ambient​ 5 days​
Refrigerate​ 7 days​
Frozen​ 3 months​
Rejection Criteria
Samples collected with potassium oxalate, sodium citrate or sodium fluoride preservatives.
Useful For
Creatine kinase (CK) is widely distributed in the tissues of the body, with greatest activity in skeletal muscle, heart muscle and the brain.  Any damage to these tissues will result in increased excretion of CK into the blood stream.  Some conditions that contribute to increased CK include Duchenne-type muscular dystrophy, myocardial infarction, central nervous system disorders, hypothyroidism, Reye’s syndrome and other muscle trauma (surgery, injuries, severe exercise).  ​
Reference Range Information
Performing Location Reference Range
All Performing Sites using Dimension Male: 50-235 IU/L
Female: 36-170 IU/L​
​Marshfield ​Male: 46-217 U/L
Female: 33-157 U/L​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Diagnostic Treatment Center​ ​Monday through Sunday​​​ ​Less than 2 hours​ ​Coupled Enzyme Reaction/Siemens Dimension
​Eau Claire ​Monday through Sunday​​​ ​Less than 2 hours​ ​​Coupled Enzyme Reaction/Siemens Dimension
​Flambeau Hospital ​Monday through Sunday​​​ ​Less than 2 hours​ ​​Coupled Enzyme Reaction/Siemens Dimension
​Ladysmith Medical Center ​Monday through Sunday ​Less than 2 hours​ ​​Coupled Enzyme Reaction/Siemens Dimension
​Lakeview Medical Center ​Monday through Sunday​​​ ​Less than 2 hours​ ​​Coupled Enzyme Reaction/Siemens Dimension
Marshfield​ Monday through Sunday​​​ Less than 2 hours​ IFCC-CK (NAC) Rate Assay/Beckman AU
​Minocqua ​Monday through Sunday​​​ ​Less than 2 hours​ ​​Coupled Enzyme Reaction/Siemens Dimension
​Neillsville​Monday through Sunday​Less than 2 hours​Coupled Enzyme Reaction/Siemens Dimension
​Wausau ​Monday through Sunday​​​ ​Less than 2 hours​ ​​Coupled Enzyme Reaction/Siemens Dimension
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
82550 ​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.