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22460 Complement, C-1Q (C1Q)

Complement, C-1Q (C1Q)
Test Code: C1QSO
Synonyms/Keywords
C1Q (Complement Component C1Q) Serum, Complement Component C1q, First Component of Complement
Useful For
Assessment of an undetectable total complement (CH[50]) level
Diagnosing congenital C1 (first component of complement) deficiency
Diagnosing acquired deficiency of C1 inhibitor
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​1 mL ​0.5 mL ​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ ​ ​Refrigerated (preferred) ​28 days
​Ambient ​21 days
​Frozen ​28 days
Rejection Criteria

Gross Lipemia

Interference

​This is a different assay than C1q binding, which is an assay for circulating immune complexes.

Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
Mayo Clinic Laboratories​​
Monday through Friday
​		 1 to 3 days ​
Nephelometry
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Performing Location Reference Range
Mayo Clinic Laboratories​​ 12-22 mg/dL
Interpretation

An undetectable C1q in the presence of an absent total complement (CH50) and normal C2, C3, and C4 suggests a congenital C1 (first component of complement) deficiency.

A low C1q in combination with a low C1 inhibitor and low C4 suggests an acquired C1 inhibitor deficiency.

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86160 ​ ​ ​ ​
Synonyms/Keywords
C1Q (Complement Component C1Q) Serum, Complement Component C1q, First Component of Complement
Ordering Applications
Ordering Application Description
​Centricity ​Complement C1Q, S (8851)
​Cerner ​Complement C1q, S (8851)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Serum​ ​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​1 mL ​0.5 mL ​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ ​ ​Refrigerated (preferred) ​28 days
​Ambient ​21 days
​Frozen ​28 days
Rejection Criteria

Gross Lipemia

Interference

​This is a different assay than C1q binding, which is an assay for circulating immune complexes.

Useful For
Assessment of an undetectable total complement (CH[50]) level
Diagnosing congenital C1 (first component of complement) deficiency
Diagnosing acquired deficiency of C1 inhibitor
Reference Range Information
Performing Location Reference Range
Mayo Clinic Laboratories​​ 12-22 mg/dL
Interpretation

An undetectable C1q in the presence of an absent total complement (CH50) and normal C2, C3, and C4 suggests a congenital C1 (first component of complement) deficiency.

A low C1q in combination with a low C1 inhibitor and low C4 suggests an acquired C1 inhibitor deficiency.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
Mayo Clinic Laboratories​​
Monday through Friday
​		 1 to 3 days ​
Nephelometry
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86160 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.