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22288 Clozapine (CLZ)

Clozapine (CLZ)
Test Code: CLOZ-SO
Synonyms/Keywords
Clozapine (Clozaril), Clozaril (Clozapine) 
Useful For

​Monitoring patient compliance

An aid to achieving desired plasma levels

Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum Red Red Top Tube (RTT)​ ​ 1 mL​ 0.6 mL​ ​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Red ​ ​ Refrigerated (preferred)​ 28 days​
Ambient ​ 7 days​
Frozen ​ 28 days​
Rejection Criteria
Serum gel tube
 
Gross Icterus
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
Mayo Clinic Laboratories​
Monday through Friday​
3 to 4 days​
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)​
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
Clozapine: Therapeutic range: 350-600 ng/mL
Norclozapine:  Not well established
Clozapine + Norclozapine: Not well established
Interpretation
​The effectiveness of clozapine treatment should be based on clinical response and treatment should be discontinued in patients failing to show an acceptable clinical response.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80159 ​ ​ ​ ​
Synonyms/Keywords
Clozapine (Clozaril), Clozaril (Clozapine) 
Ordering Applications
Ordering Application Description
​Centricity ​Clozapine (Clozaril) (CLZ)
​Cerner ​Clozaphine Level (500406)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​Serum Red Red Top Tube (RTT)​ ​ 1 mL​ 0.6 mL​ ​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Red ​ ​ Refrigerated (preferred)​ 28 days​
Ambient ​ 7 days​
Frozen ​ 28 days​
Rejection Criteria
Serum gel tube
 
Gross Icterus
Useful For

​Monitoring patient compliance

An aid to achieving desired plasma levels

Reference Range Information
Clozapine: Therapeutic range: 350-600 ng/mL
Norclozapine:  Not well established
Clozapine + Norclozapine: Not well established
Interpretation
​The effectiveness of clozapine treatment should be based on clinical response and treatment should be discontinued in patients failing to show an acceptable clinical response.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
Mayo Clinic Laboratories​
Monday through Friday​
3 to 4 days​
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80159 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.