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22223 Amino Acids Panel, Urine (AAPD)

Amino Acids Panel, Urine (AAPD)
Test Code: AAIERSO
Synonyms/Keywords
​1-Methylhistidine, 3-Methylhistidine, Alanine, Allo-Isoleucine, Alpha-Aminoadipic Acid, Alpha-Amino-n-Butyric Acid, Anserine, Arginine, Argininosuccinic Acid, Asparagine, Aspartic Acid, Beta-Alanine, Beta-Aminoisobutyric Acid, Carnosine, Citrulline, Cystathionine, Ethanolamine, Gamma-Amino-n-Butyric Acid, Glutamic Acid, Glutamine, Glycine, Histidine, Homocitrulline, Hydroxylysine, Hydroxyproline, Isoleucine, Leucine, Lysine, Methionine, Ornithine, Phenylalanine, Phosphoethanolamine, Phosphoserine, Proline, Sarcosine, Serine, Taurine, Threonine, Tryptophan, Tyrosine, Valine, Cystine, U AAIERSO, Amino Acid Panel, Urine (AAPD)
Test Components
Includes quantitation of the following amino acids: phosphoserine, phosphoethanolamine, taurine, threonine, serine, asparagine, hydroxyproline, glutamic acid, glutamine, aspartic acid, ethanolamine, sarcosine, proline, glycine, alanine, citrulline, alpha-aminoadipic acid, alpha-amino-n-butyric acid, valine, cystine, cystathionine, methionine, isoleucine, leucine, tyrosine, phenylalanine, beta-alanine, beta-aminoisobutyric acid, ornithine, lysine, 1-methylhistidine, histidine, 3-methylhistidine, carnosine, anserine, argininosuccinic acid, allo-isoleucine, homocitrulline, gamma-amino-n-butyric acid, hydroxylysine, tryptophan, and arginine.
Useful For
​Evaluating patients with possible inborn errors of metabolism
 
May aid in evaluation of endocrine disorders, liver diseases, muscle diseases, neoplastic diseases, neurological disorders, nutritional disturbances, renal failure, and burns
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Random ​Urine Plastic, 6-mL tube ​ 2 mL 1 mL ​
Collection Processing Instructions

Collect a random urine specimen.​

1. Patient's age is required.

2. Include family history, clinical condition (asymptomatic or acute episode), diet, and drug therapy information.

3. If prolidase deficiency is a concern, indicate on the amino acid order "Pretreat with acid hydrolysis prior to analysis". The acid hydrolysis will break up in-vitro proline and hydroxyproline containing dipeptides, which in vivo are cleaved by prolidase.

Specimen Stability Information
Specimen Type Temperature Time
​Urine ​Frozen (preferred) ​70 days
​ ​Refrigerated ​14 days
Rejection Criteria

​All specimens will be evaluated at Mayo Clinic Laboratories for test suitability. 

Interference

​Not all patients with homocystinuria and prolidase deficiency will be detected by this assay. See Additional Testing Requirements and Necessary Information for more information.

Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories​
 Monday through Friday​ 3 to 5 days Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)​
Reference Lab
Mayo Clinic Laboratories
Reference Range Information
See Mayo Clinic Laboratories for age specific reference ranges. 
Interpretation
When no significant abnormalities are detected, a simple descriptive interpretation is provided. When abnormal results are detected, a detailed interpretation is given, including an overview of the results and of their significance, a correlation to available clinical information, elements of differential diagnosis, recommendations for additional biochemical testing and in vitro confirmatory studies (enzyme assay, molecular analysis), name and phone number of key contacts who may provide these studies, and a phone number to reach one of the laboratory directors in case the referring physician has additional questions.
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82139 ​ ​ ​ ​
Synonyms/Keywords
​1-Methylhistidine, 3-Methylhistidine, Alanine, Allo-Isoleucine, Alpha-Aminoadipic Acid, Alpha-Amino-n-Butyric Acid, Anserine, Arginine, Argininosuccinic Acid, Asparagine, Aspartic Acid, Beta-Alanine, Beta-Aminoisobutyric Acid, Carnosine, Citrulline, Cystathionine, Ethanolamine, Gamma-Amino-n-Butyric Acid, Glutamic Acid, Glutamine, Glycine, Histidine, Homocitrulline, Hydroxylysine, Hydroxyproline, Isoleucine, Leucine, Lysine, Methionine, Ornithine, Phenylalanine, Phosphoethanolamine, Phosphoserine, Proline, Sarcosine, Serine, Taurine, Threonine, Tryptophan, Tyrosine, Valine, Cystine, U AAIERSO, Amino Acid Panel, Urine (AAPD)
Test Components
Includes quantitation of the following amino acids: phosphoserine, phosphoethanolamine, taurine, threonine, serine, asparagine, hydroxyproline, glutamic acid, glutamine, aspartic acid, ethanolamine, sarcosine, proline, glycine, alanine, citrulline, alpha-aminoadipic acid, alpha-amino-n-butyric acid, valine, cystine, cystathionine, methionine, isoleucine, leucine, tyrosine, phenylalanine, beta-alanine, beta-aminoisobutyric acid, ornithine, lysine, 1-methylhistidine, histidine, 3-methylhistidine, carnosine, anserine, argininosuccinic acid, allo-isoleucine, homocitrulline, gamma-amino-n-butyric acid, hydroxylysine, tryptophan, and arginine.
Ordering Applications
Ordering Application Description
​COM​Amino Acid Panel Qnt. Random Urine (AAPD)
​Cerner ​Amino Acid Panel, Urine (AAPD)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
Random ​Urine Plastic, 6-mL tube ​ 2 mL 1 mL ​
Collection Processing

Collect a random urine specimen.​

1. Patient's age is required.

2. Include family history, clinical condition (asymptomatic or acute episode), diet, and drug therapy information.

3. If prolidase deficiency is a concern, indicate on the amino acid order "Pretreat with acid hydrolysis prior to analysis". The acid hydrolysis will break up in-vitro proline and hydroxyproline containing dipeptides, which in vivo are cleaved by prolidase.

Specimen Stability Information
Specimen Type Temperature Time
​Urine ​Frozen (preferred) ​70 days
​ ​Refrigerated ​14 days
Rejection Criteria

​All specimens will be evaluated at Mayo Clinic Laboratories for test suitability. 

Interference

​Not all patients with homocystinuria and prolidase deficiency will be detected by this assay. See Additional Testing Requirements and Necessary Information for more information.

Useful For
​Evaluating patients with possible inborn errors of metabolism
 
May aid in evaluation of endocrine disorders, liver diseases, muscle diseases, neoplastic diseases, neurological disorders, nutritional disturbances, renal failure, and burns
Test Components
Includes quantitation of the following amino acids: phosphoserine, phosphoethanolamine, taurine, threonine, serine, asparagine, hydroxyproline, glutamic acid, glutamine, aspartic acid, ethanolamine, sarcosine, proline, glycine, alanine, citrulline, alpha-aminoadipic acid, alpha-amino-n-butyric acid, valine, cystine, cystathionine, methionine, isoleucine, leucine, tyrosine, phenylalanine, beta-alanine, beta-aminoisobutyric acid, ornithine, lysine, 1-methylhistidine, histidine, 3-methylhistidine, carnosine, anserine, argininosuccinic acid, allo-isoleucine, homocitrulline, gamma-amino-n-butyric acid, hydroxylysine, tryptophan, and arginine.
Reference Range Information
See Mayo Clinic Laboratories for age specific reference ranges. 
Interpretation
When no significant abnormalities are detected, a simple descriptive interpretation is provided. When abnormal results are detected, a detailed interpretation is given, including an overview of the results and of their significance, a correlation to available clinical information, elements of differential diagnosis, recommendations for additional biochemical testing and in vitro confirmatory studies (enzyme assay, molecular analysis), name and phone number of key contacts who may provide these studies, and a phone number to reach one of the laboratory directors in case the referring physician has additional questions.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Clinic Laboratories​
 Monday through Friday​ 3 to 5 days Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)​
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​82139 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.