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25097 Oxycodone, Urine, Confirm Only by LCMSMS

Oxycodone, Urine, Confirm Only by LCMSMS
Test Code: CO-OXY
Synonyms/Keywords
​Oxycodone, Oxymorphone, Oxycontin, Percodan, Percocet, Opana
Useful For
Detecting exposure to oxycodone and/or oxmorphone to monitor compliance in taking prescribed medications or to detect abuse.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 2 mL​ 1 mL​ 0.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Ambient​ 72 hours​
Refrigerate (Preferred)​ 30 days
Frozen​ 30 days​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 2-4 days​ Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
 
This test is an LCMS/MS confirmation only for oxycodone and oxymorphone. It is intended for use only in patients where an intial drug screening test has already been performed at the time of specimen collection (i.e. Point-of-Care drug screening cup, dipstick, etc.) The specimen will not be screened by immunoassay in the laboratory; it will only be tested by LCMS/MS. If an initial drug screen has not been performed at the specimen collection site, it is more appropriate to order the "Oxycodone, Urine" test code (OXY) which includes an initial screen.
 
Oxycodone and oxymorphone are opiods (semisynthetic narcotic analgesics derived from the compound thebane which occurs naturally in opium). Oxycodone is available in many preparations for oral use including Percodan, Percocet, and Oxycontin. Oxycodone is partially metabolized in the body to oxymorphone. Oxymorphone is also available in an oral preparation to treat chronic pain. ​
Reference Range Information
Performing Location Reference Range
Marshfield​ Negative.  Positives are reported with a quantitative LCMS/MS result.​
Interpretation

Current Cutoff Levels for Toxicology

1. Oxycodone metabolizes to oxymorphone.
2. Hydrocodone can be a pharmaceutical impurity of the Oxycodone production process.  It may be present in very small amounts with high levels of Oxycodone (less than 4% of the oxycodone level).
3. Oxycodone and Hydromorphone can be pharmaceutical impurities of the Oxymorphone production process.  If either are present at levels less than or equal to 0.5% of the Oxymorphone level, it is likely an impurity and not evidence of use of Oxycodone and/or Hydromorphone.

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80365 ​ ​1 Oxycodone Confirmation by LC/MS/MS
​G0480 ​ ​1 ​Oxycodone Confirmation by LC/MS/MS ​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Synonyms/Keywords
​Oxycodone, Oxymorphone, Oxycontin, Percodan, Percocet, Opana
Ordering Applications
Ordering Application Description
​Cerner ​Oxycodone, Urine, Confirm Only by LCMSMS
​COM ​Oxycodone, Urine, Confirm
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 2 mL​ 1 mL​ 0.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Ambient​ 72 hours​
Refrigerate (Preferred)​ 30 days
Frozen​ 30 days​
Useful For
Detecting exposure to oxycodone and/or oxmorphone to monitor compliance in taking prescribed medications or to detect abuse.
Reference Range Information
Performing Location Reference Range
Marshfield​ Negative.  Positives are reported with a quantitative LCMS/MS result.​
Interpretation

Current Cutoff Levels for Toxicology

1. Oxycodone metabolizes to oxymorphone.
2. Hydrocodone can be a pharmaceutical impurity of the Oxycodone production process.  It may be present in very small amounts with high levels of Oxycodone (less than 4% of the oxycodone level).
3. Oxycodone and Hydromorphone can be pharmaceutical impurities of the Oxymorphone production process.  If either are present at levels less than or equal to 0.5% of the Oxymorphone level, it is likely an impurity and not evidence of use of Oxycodone and/or Hydromorphone.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 2-4 days​ Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​80365 ​ ​1 Oxycodone Confirmation by LC/MS/MS
​G0480 ​ ​1 ​Oxycodone Confirmation by LC/MS/MS ​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
For most current information refer to the Marshfield Laboratory online reference manual.