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Lab Test Reference Manual
Human Reference Manual
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22192
Lab Test Reference Manual
Human Reference Manual
Currently selected
22192
CEA, Body Fluid
Marshfield Lab Public WebSite
Marshfield Clinic Public WebSite
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Site Contents
CEA, Body Fluid
Test Code: CEA-O
Overview
Ordering
Specimen
Performing
Clinical/Interpretive
Contacts
Coding
Synonyms/Keywords
Synonyms, Keywords
Body Fluid CEA, Carcinoembryonic Ag-Other
Useful For
Useful For
Aids in distinguishing between mucinous and non-mucinous pancreatic cysts and likelihood of a malignant pancreatic cyst when used in conjunction with imaging studies cytology and other pancreatic cyst tumor markers.
An adjuvant to cytology and imaging studies to differentiate between nonmalignant and malignant causes of pleural effusions & peritoneal fluid.
Specimen Requirements
Specimen Requirements
Specimen Type
Preferred Container/Tube
Acceptable Container/Tube
Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Pancreatic Cyst Fluid / Body Fluid
Body Fluid Container
Plastic Vial
300 uL
100 uL
N/A
Collection Processing Instructions
Collection Processing
Do not collect the specimen with preservatives or anticoagulants. Specimens should be centrifuged to remove cells or clots, if present.
Specimen Stability Information
Specimen Stability Information
Specimen Type
Temperature
Time
Panceratic Cyst Fluid / Body Fluid
Ambient
N/A
Refrigerated
7 days
Frozen at -20 deg Celsius
30 days
Frozen at -70 deg Celsius
> 30 Days
One freeze and thaw cycle acceptable
Rejection Criteria
Rejection Criteria
Blood or Urine
Interference
Interference
The possibility exists for interference by heterophile antibodies & HAMA in the patient sample regularly exposed to animals or has received immunotherapy or diagnostic procedures utilizing immunoglobulins or immunoglobulin fragments.
Performing Laboratory Information
Performing Laboratory Information
Performing Location
Day(s) Test Performed
Analytical Time
Methodology/Instrumentation
Marshfield
Monday through Sunday
Less than 2 hours
Two-step Sandwich Immunoassay using Direct Chemiluminometric Technology/Siemens Centaur
Reference Range Information
Reference Range Information
Performing Location
Reference Range
Marshfield
Reference cut-off limits for CEA for pancreatic cyst fluid and other body fluids have not been established and verified.
The test results should not be the sole basis of diagnosis and always be correlated with imaging and cytology.
Interpretation
Interpretations
Diagnosis of a pancreatic cyst is often difficult and requires correlation of imaging studies, cytology studies and tumor marker results on cyst aspirates. Carcinoembryonic antigen (CEA) has been found to be most helpful tumor marker in differentiating between mucinous and non-mucinous pancreatic cysts. Higher concentrations of CEA have greater likelihood that mucinous cyst may be malignant but CEA does not distinguish between benign, premalignant or malignant mucinous cysts.
Based on evidence available and recommendations by the American College of Gastroenterology (ACG) practice guidelines for the Diagnosis and Management of Neoplastic Pancreatic Cysts (Am. J. Gastroenterol. 2007; 102: 2339-2349), a pancreatic cyst fluid CEA concentration > 800 ng/ml has high specificity to exclude pseudocysts and concentration > 200 ng/mL is suggestive but not diagnostic of mucinous cyst. Cyst fluid concentrations of <= 5 ng/ml indicate low risk for mucinous cyst and are more consistent of serous cystadenoma.
This test does not distinguish between malignant and non-malignant mucinous cysts. Test should not be ordered for pancreatic fluid of non-cyst origin.
Outreach CPTs
Outreach CPT Codes
CPT
Modifier
(if needed)
Quantity
Description
Comments
82378
Synonyms/Keywords
Synonyms, Keywords
Body Fluid CEA, Carcinoembryonic Ag-Other
Ordering Applications
Ordering Applications
Ordering Application
Description
Centricity
CEA
Cerner
CEA, Body Fluid
COM
CEA-Other
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Requirements
Specimen Type
Preferred Container/Tube
Acceptable Container/Tube
Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Pancreatic Cyst Fluid / Body Fluid
Body Fluid Container
Plastic Vial
300 uL
100 uL
N/A
Collection Processing
Collection Processing
Do not collect the specimen with preservatives or anticoagulants. Specimens should be centrifuged to remove cells or clots, if present.
Specimen Stability Information
Specimen Stability Information
Specimen Type
Temperature
Time
Panceratic Cyst Fluid / Body Fluid
Ambient
N/A
Refrigerated
7 days
Frozen at -20 deg Celsius
30 days
Frozen at -70 deg Celsius
> 30 Days
One freeze and thaw cycle acceptable
Rejection Criteria
Rejection Criteria
Blood or Urine
Interference
Interference
The possibility exists for interference by heterophile antibodies & HAMA in the patient sample regularly exposed to animals or has received immunotherapy or diagnostic procedures utilizing immunoglobulins or immunoglobulin fragments.
Useful For
Useful For
Aids in distinguishing between mucinous and non-mucinous pancreatic cysts and likelihood of a malignant pancreatic cyst when used in conjunction with imaging studies cytology and other pancreatic cyst tumor markers.
An adjuvant to cytology and imaging studies to differentiate between nonmalignant and malignant causes of pleural effusions & peritoneal fluid.
Reference Range Information
Reference Range Information
Performing Location
Reference Range
Marshfield
Reference cut-off limits for CEA for pancreatic cyst fluid and other body fluids have not been established and verified.
The test results should not be the sole basis of diagnosis and always be correlated with imaging and cytology.
Interpretation
Interpretations
Diagnosis of a pancreatic cyst is often difficult and requires correlation of imaging studies, cytology studies and tumor marker results on cyst aspirates. Carcinoembryonic antigen (CEA) has been found to be most helpful tumor marker in differentiating between mucinous and non-mucinous pancreatic cysts. Higher concentrations of CEA have greater likelihood that mucinous cyst may be malignant but CEA does not distinguish between benign, premalignant or malignant mucinous cysts.
Based on evidence available and recommendations by the American College of Gastroenterology (ACG) practice guidelines for the Diagnosis and Management of Neoplastic Pancreatic Cysts (Am. J. Gastroenterol. 2007; 102: 2339-2349), a pancreatic cyst fluid CEA concentration > 800 ng/ml has high specificity to exclude pseudocysts and concentration > 200 ng/mL is suggestive but not diagnostic of mucinous cyst. Cyst fluid concentrations of <= 5 ng/ml indicate low risk for mucinous cyst and are more consistent of serous cystadenoma.
This test does not distinguish between malignant and non-malignant mucinous cysts. Test should not be ordered for pancreatic fluid of non-cyst origin.
For more information visit:
http://labtestsonline.org
Performing Laboratory Information
Performing Laboratory Information
Performing Location
Day(s) Test Performed
Analytical Time
Methodology/Instrumentation
Marshfield
Monday through Sunday
Less than 2 hours
Two-step Sandwich Immunoassay using Direct Chemiluminometric Technology/Siemens Centaur
For billing questions, see Contacts
Outreach CPTs
Outreach CPT Codes
CPT
Modifier
(if needed)
Quantity
Description
Comments
82378
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For most current information refer to the Marshfield Laboratory online reference manual.