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# A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Serum Trypsin-Like Immunoreactivity (TLI), Feline
Test Code: VTLIFSO
Synonyms/Keywords
​Exocrine Pancreatic Insufficiency  (EPI)
Species
Feline
Test Category
Specimen Requirements
Fasting Required Specimen Type​ Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)

Yes

12-18 hour fast for non-diabetic animals

6 hour fast for diabetic animals

​Serum Red Top Tube (RTT)​ Serum Separator Tube (SST)​ ​0.5 mL 0.2 mL​
Collection Processing Instructions
​Samples are stable at room temperature and refrigerated for each stated stability, but are preferred frozen as soon as possible.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ Room Temperature 2 weeks
​Refrigerated 1 month
​Frozen (preferred) Indefinitely
Interference
​Hemolysis and non-fasting status may interfere with results.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Texas A&M Gastrointestinal Lab​ Monday through Friday​ ​1-2 Days RIA
Marshfield Center Laboratory Section
Reference Lab
Reference Lab Information
Address Telephone Website Link Marshfield Lab Account #

Gastrointestinal Laboratory
4474 TAMU
College of Veterinary Medicine
Texas A&M University
College Station, TX 77843-4474​

Ph 979-862-2861

Fax 979-862-2864

vetmed.tamu.edu/gilab 68-026314​
Test Information

In cats, values equal to or below 8.0 µg/L are diagnostic for EPI, with values between 8.0 and 12.0 being equivocal. As in the dog, repeating the assay one month later should be considered.

Serum TLI values above 50.0 µg/L (dogs) and 100.0 µg/L (cats) are consistent with either acute or chronic pancreatitis or decreased renal excretion due to severe renal insufficiency, although our experience suggests that serum TLI is often minimally increased even in severe renal failure. Elevated serum TLI concentrations are also seen in some malnourished patients (dogs usually) without evidence of pancreatitis, and in some cats with patchy pancreatic hypertrophy/atrophy (generally considered to be a benign age-related change). Serum TLI is increased in approximately 30-40% of cats and dogs with pancreatitis; it is important to recognize that normal test results do not rule out the possibility of pancreatic inflammation. We believe that in acute pancreatitis testing of samples obtained as soon as possible after the onset of clinical signs is most likely to yield an abnormal test result. If pancreatitis is suspected, a PLI test should be performed. In cats increased serum TLI is often also observed with small intestinal disease. In these cases serum concentrations of cobalamin and folate should be determined for evaluation of the small intestine.

Administration of oral pancreatic extracts does not affect serum TLI concentrations in either normal dogs or cats with EPI, so withdrawal of enzyme supplementation prior to testing of dogs and cats that are already receiving supplementation is unnecessary.

Reference Intervals
Performing Location Reference Intervals
​Texas A&M Gastrointestinal Lab 12.0 - 82.0 ug/mL​
Synonyms/Keywords
​Exocrine Pancreatic Insufficiency  (EPI)
Species
Feline
Test Category
Specimen Requirements
Fasting Required Specimen Type​ Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)

Yes

12-18 hour fast for non-diabetic animals

6 hour fast for diabetic animals

​Serum Red Top Tube (RTT)​ Serum Separator Tube (SST)​ ​0.5 mL 0.2 mL​
Collection Processing Instructions
​Samples are stable at room temperature and refrigerated for each stated stability, but are preferred frozen as soon as possible.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ Room Temperature 2 weeks
​Refrigerated 1 month
​Frozen (preferred) Indefinitely
Interference
​Hemolysis and non-fasting status may interfere with results.
Test Information

In cats, values equal to or below 8.0 µg/L are diagnostic for EPI, with values between 8.0 and 12.0 being equivocal. As in the dog, repeating the assay one month later should be considered.

Serum TLI values above 50.0 µg/L (dogs) and 100.0 µg/L (cats) are consistent with either acute or chronic pancreatitis or decreased renal excretion due to severe renal insufficiency, although our experience suggests that serum TLI is often minimally increased even in severe renal failure. Elevated serum TLI concentrations are also seen in some malnourished patients (dogs usually) without evidence of pancreatitis, and in some cats with patchy pancreatic hypertrophy/atrophy (generally considered to be a benign age-related change). Serum TLI is increased in approximately 30-40% of cats and dogs with pancreatitis; it is important to recognize that normal test results do not rule out the possibility of pancreatic inflammation. We believe that in acute pancreatitis testing of samples obtained as soon as possible after the onset of clinical signs is most likely to yield an abnormal test result. If pancreatitis is suspected, a PLI test should be performed. In cats increased serum TLI is often also observed with small intestinal disease. In these cases serum concentrations of cobalamin and folate should be determined for evaluation of the small intestine.

Administration of oral pancreatic extracts does not affect serum TLI concentrations in either normal dogs or cats with EPI, so withdrawal of enzyme supplementation prior to testing of dogs and cats that are already receiving supplementation is unnecessary.

Reference Intervals
Performing Location Reference Intervals
​Texas A&M Gastrointestinal Lab 12.0 - 82.0 ug/mL​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Texas A&M Gastrointestinal Lab​ Monday through Friday​ ​1-2 Days RIA
Laboratory Section
Reference Lab
Reference Lab Information
Address Telephone Website Link Marshfield Lab Account #

Gastrointestinal Laboratory
4474 TAMU
College of Veterinary Medicine
Texas A&M University
College Station, TX 77843-4474​

Ph 979-862-2861

Fax 979-862-2864

vetmed.tamu.edu/gilab 68-026314​
For most current information refer to the Marshfield Laboratory online reference manual.