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455 Canine Urine Cortisol/Creatinine Ratio

Canine Urine Cortisol/Creatinine Ratio
Test Code: VCORCR
Synonyms/Keywords
Urine Cortisol/Creatinine Ratio
Test Components
Cortisol/Creat Ratio Urine (VCORTCR)
Creatinine Urine (VUCRMML)
Species
Canine
Test Category
Specimen Requirements

 

Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
​Urine, Random ​Tube or container without preservative ​5.0 mL ​2.5 mL
Collection Processing Instructions

Collect sample in a low stress environment. It is recommended that owner collect morning urine samples at home. Samples collected after a journey to, or a visit/stay in and veterinary clinic, are more likely to yield falsely elevated results.  One sample, or 2 samples collected on separate days and pooled, may be submitted. 
Label tube with animal’s name.

Specimen Stability Information
Specimen Type Temperature Time
​Urine ​Refrigerate ​1 week
​Freeze ​1 month
Rejection Criteria
Specimens with preservative
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday and Thursday ​6-8 hours
Waters TQ-XS UPLC MS/MS
Creatinine performed in the 24HS Chemistry Lab; Urine Cortisol performed in Special Chemistry.
Samples must be in the performing department by 8 am on the day of testing for results the next day.​ ​ ​ ​
Marshfield Center Laboratory Section
Reference Intervals
Performing Location Reference Intervals
Marshfield ​Cortisol/Creatinine Ratio = 0.0-5.0 nmol cortisol/mmol creatinine 
Interpretation
This test is a useful test to rule out hyperadrenocorticism, but not useful to diagnosis hyperadrenocorticism. Urine Cortisol/Creatinine Ratio < 0.5; dog is unlikely to have hyperadrenocorticism. Urine Cortisol/Creatinine Ratio > 0.5; dog may have hyperadrenocorticism or may be stressed or have a non-adrenal illness.
Synonyms/Keywords
Urine Cortisol/Creatinine Ratio
Test Components
Cortisol/Creat Ratio Urine (VCORTCR)
Creatinine Urine (VUCRMML)
Species
Canine
Test Category
Specimen Requirements

 

Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
​Urine, Random ​Tube or container without preservative ​5.0 mL ​2.5 mL
Collection Processing Instructions

Collect sample in a low stress environment. It is recommended that owner collect morning urine samples at home. Samples collected after a journey to, or a visit/stay in and veterinary clinic, are more likely to yield falsely elevated results.  One sample, or 2 samples collected on separate days and pooled, may be submitted. 
Label tube with animal’s name.

Specimen Stability Information
Specimen Type Temperature Time
​Urine ​Refrigerate ​1 week
​Freeze ​1 month
Rejection Criteria
Specimens with preservative
Reference Intervals
Performing Location Reference Intervals
Marshfield ​Cortisol/Creatinine Ratio = 0.0-5.0 nmol cortisol/mmol creatinine 
Interpretation
This test is a useful test to rule out hyperadrenocorticism, but not useful to diagnosis hyperadrenocorticism. Urine Cortisol/Creatinine Ratio < 0.5; dog is unlikely to have hyperadrenocorticism. Urine Cortisol/Creatinine Ratio > 0.5; dog may have hyperadrenocorticism or may be stressed or have a non-adrenal illness.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday and Thursday ​6-8 hours
Waters TQ-XS UPLC MS/MS
Creatinine performed in the 24HS Chemistry Lab; Urine Cortisol performed in Special Chemistry.
Samples must be in the performing department by 8 am on the day of testing for results the next day.​ ​ ​ ​
Laboratory Section
For most current information refer to the Marshfield Laboratory online reference manual.