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# A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Tacrolimus
Test Code: VTACRO
Synonyms/Keywords
​​FK506, Prograf​
Species
Alpaca, Avian, Bovine, Canine, Camelid, Caprine, Equine, Feline, Ferret, Mouse, Other, Ovine, Porcine, Primate, Rabbit, Rat
Test Category
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
​Whole blood ​EDTA Lavender Top Tube (LTT) ​3 mL ​1 mL
Collection Processing Instructions
​1. Draw blood immediately before a schedule dose.
2. Do not centrifuge.
3. Send specimen in original tube.
 
Additional Information:
1. Therapeutic range applies to trough specimens drawn immediately prior to a.m. dose.
2. If sirolimus analysis is desired, draw and send another tube.  Tests can not be combined.
Specimen Stability Information
Specimen Type Temperature Time
​Whole blood ​ ​ ​Refrigerate (preferred) ​14 days
​Ambient ​14 days
​Frozen ​14 days
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday through Friday (Prior to noon) ​1 day ​Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring
Marshfield Center Laboratory Section
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
Reference Intervals
Performing Location Reference Intervals
​Marshfield ​See Report
Interpretation
​Most individuals display optimal response to tacrolimus with trough whole blood levels of 5.0 ng/mL to 15.0 ng/mL. Preferred therapeutic ranges may vary by transplant type, protocol, and comedications.
Therapeutic ranges are based on samples drawn at trough (ie, immediately before a scheduled dose). Blood drawn at other times will yield higher results.
 
The assay is specific for tacrolimus; it does not cross-react with cyclosporine, cyclosporine metabolites, sirolimus, sirolimus metabolites, or tacrolimus metabolites. Results by liquid chromatography with detection by tandem mass spectrometry are approximately 30% less than by immunoassay.
Synonyms/Keywords
​​FK506, Prograf​
Species
Alpaca, Avian, Bovine, Canine, Camelid, Caprine, Equine, Feline, Ferret, Mouse, Other, Ovine, Porcine, Primate, Rabbit, Rat
Test Category
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
​Whole blood ​EDTA Lavender Top Tube (LTT) ​3 mL ​1 mL
Collection Processing Instructions
​1. Draw blood immediately before a schedule dose.
2. Do not centrifuge.
3. Send specimen in original tube.
 
Additional Information:
1. Therapeutic range applies to trough specimens drawn immediately prior to a.m. dose.
2. If sirolimus analysis is desired, draw and send another tube.  Tests can not be combined.
Specimen Stability Information
Specimen Type Temperature Time
​Whole blood ​ ​ ​Refrigerate (preferred) ​14 days
​Ambient ​14 days
​Frozen ​14 days
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
Reference Intervals
Performing Location Reference Intervals
​Marshfield ​See Report
Interpretation
​Most individuals display optimal response to tacrolimus with trough whole blood levels of 5.0 ng/mL to 15.0 ng/mL. Preferred therapeutic ranges may vary by transplant type, protocol, and comedications.
Therapeutic ranges are based on samples drawn at trough (ie, immediately before a scheduled dose). Blood drawn at other times will yield higher results.
 
The assay is specific for tacrolimus; it does not cross-react with cyclosporine, cyclosporine metabolites, sirolimus, sirolimus metabolites, or tacrolimus metabolites. Results by liquid chromatography with detection by tandem mass spectrometry are approximately 30% less than by immunoassay.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday through Friday (Prior to noon) ​1 day ​Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring
Laboratory Section
For most current information refer to the Marshfield Laboratory online reference manual.