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# A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Metanephrine Fractionation, Urine, Canine
Test Code: VMETRND
Synonyms/Keywords
Metanephrine, Normetanephrine (Metanephrine metabolite)
Test Components

Metanephrine/Creatinine Ratio

Normetanephrine/Creatinine Ratio

Species
Canine
Test Category
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
​Urine, Random Pre-weighed 0.01 g sulfamic acid aliquot tube Any sterile plastic tube or sage cup ​5.0 mL ​3.0 mL
Collection Processing Instructions
Collect urine in a clean container and pour into pre-weighed 0.01 gram sulfamic acid aliquot tube provided by Marshfield Lab. Acceptable alternative preservative is to add a few granules of sulfamic acid or acidify with dilute hydrochloric acid to a pH <5. Acid preservative needs to be added within 24 hours of collection. If preservative is not available, samples can be sent unpreserved and refrigerated if arrival in lab is less than 24 hours from collection time. If time from collection to lab arrival is greater than 24 hours, it is acceptable to immediately freeze unpreserved samples and transport frozen. Unpreserved samples will be acidified upon arrival in lab.
 
A patient control sample does not need to be submitted for this test.
Specimen Stability Information
Specimen Type Temperature Time
​Urine, Random- Preserved ​ ​Refrigerate 1 month
​Frozen ​2 months
​Urine, Random- Not Preserved ​ ​Refrigerate ​24 hours
​Frozen ​2 weeks
Rejection Criteria
​Specimens unpreserved and not frozen >24 hrs.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday and Thursday ​24 hours ​LC/MS MS
Creatinine performed in the 24HS Chemistry Lab; Normetanephrine and Metanephrine performed in Special Chemistry.​ ​ ​ ​
Samples must be in the performing department by 8 am on the day of testing for results the next day.​
Samples needing repeat testing due to high result will be repeated with the next scheduled run.  Results will not be available until the repeat analysis is performed.
Marshfield Center Laboratory Section
Reference Lab Information
​end range for Creat
Reference Intervals
Performing Location Reference Intervals
​Marshfield

Canine Reference Range:

Normetanephrine/Creatinine Ratio = 28-380 ug/g Creatinine

Metanephrine/Creatinine Ratio = 18-359 ug/g Creatinine
Interpretation
 
Urinary metanephrine/normetanephrine to creatinine ratio (VMETRND) is recommended as the
primary assay to screen for pheochromocytoma.
Normetanephrine/creatinine and metanephrine/creatinine results less than 4x the upper
limit of the reference interval DO NOT support a diagnosis of pheochromocytoma.
Normetanephrine/creatinine and/or metanephrine/creatinine results greater than or equal to 4x
the upper limit of the reference interval DO support a diagnosis of pheochromocytoma.
If results are less than 4x the upper limit of the reference interval for the measured
metabolites and a pheochromocytoma remains a differential diagnosis, then consider urinary
epinephrine/norepinephrine/dopamine to creatinine (VCATRND) testing. Please keep in mind
that pheochromocytomas may secrete hormones episodically and therefore even additional
testing may not be confirmatory in some cases of pheochromocytoma.
Synonyms/Keywords
Metanephrine, Normetanephrine (Metanephrine metabolite)
Test Components

Metanephrine/Creatinine Ratio

Normetanephrine/Creatinine Ratio

Species
Canine
Test Category
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
​Urine, Random Pre-weighed 0.01 g sulfamic acid aliquot tube Any sterile plastic tube or sage cup ​5.0 mL ​3.0 mL
Collection Processing Instructions
Collect urine in a clean container and pour into pre-weighed 0.01 gram sulfamic acid aliquot tube provided by Marshfield Lab. Acceptable alternative preservative is to add a few granules of sulfamic acid or acidify with dilute hydrochloric acid to a pH <5. Acid preservative needs to be added within 24 hours of collection. If preservative is not available, samples can be sent unpreserved and refrigerated if arrival in lab is less than 24 hours from collection time. If time from collection to lab arrival is greater than 24 hours, it is acceptable to immediately freeze unpreserved samples and transport frozen. Unpreserved samples will be acidified upon arrival in lab.
 
A patient control sample does not need to be submitted for this test.
Specimen Stability Information
Specimen Type Temperature Time
​Urine, Random- Preserved ​ ​Refrigerate 1 month
​Frozen ​2 months
​Urine, Random- Not Preserved ​ ​Refrigerate ​24 hours
​Frozen ​2 weeks
Rejection Criteria
​Specimens unpreserved and not frozen >24 hrs.
Reference Intervals
Performing Location Reference Intervals
​Marshfield

Canine Reference Range:

Normetanephrine/Creatinine Ratio = 28-380 ug/g Creatinine

Metanephrine/Creatinine Ratio = 18-359 ug/g Creatinine
Interpretation
 
Urinary metanephrine/normetanephrine to creatinine ratio (VMETRND) is recommended as the
primary assay to screen for pheochromocytoma.
Normetanephrine/creatinine and metanephrine/creatinine results less than 4x the upper
limit of the reference interval DO NOT support a diagnosis of pheochromocytoma.
Normetanephrine/creatinine and/or metanephrine/creatinine results greater than or equal to 4x
the upper limit of the reference interval DO support a diagnosis of pheochromocytoma.
If results are less than 4x the upper limit of the reference interval for the measured
metabolites and a pheochromocytoma remains a differential diagnosis, then consider urinary
epinephrine/norepinephrine/dopamine to creatinine (VCATRND) testing. Please keep in mind
that pheochromocytomas may secrete hormones episodically and therefore even additional
testing may not be confirmatory in some cases of pheochromocytoma.
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield ​Monday and Thursday ​24 hours ​LC/MS MS
Creatinine performed in the 24HS Chemistry Lab; Normetanephrine and Metanephrine performed in Special Chemistry.​ ​ ​ ​
Samples must be in the performing department by 8 am on the day of testing for results the next day.​
Samples needing repeat testing due to high result will be repeated with the next scheduled run.  Results will not be available until the repeat analysis is performed.
Laboratory Section
Reference Lab Information
​end range for Creat
For most current information refer to the Marshfield Laboratory online reference manual.