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PAC1SO Paraneoplastic, Autoantibody Evaluation, Spinal Fluid (PAC1)

Paraneoplastic, Autoantibody Evaluation, Spinal Fluid (PAC1)
Test Code: PAC1SO
Synonyms/Keywords

​Amphiphysin Ab, CSF, ANNA-1, CSF, ANNA-2, CSF, ANNA-3, CSF, Anti-Hu, Antineuronal Cerebellar Antibodies, CRMP-5-IgG, CSF, Dorsal Root Ganglion Antibody, Hu Antibody, Neuron Restricted Autoantibodies, Neuronal Nuclear Antibody, Neuronal-Anti, Ovarian Cancer-Related Antibodies, Paraneoplastic Autoantibody Western Blot Confirmation, CSF, Paraneoplastic Neurological Autoimmunity, PCA-1, CSF, PCA-2, CSF, PCA-Tr, CSF, Purkinje Cell Cytoplasmic Antibodies, Ri, Anti, Yo-Anti

Useful For

​Aids in the diagnosis of paraneoplastic neurological autoimmune disorders related to carcinoma of lung, breast, ovary, thymoma, or Hodgkin lymphoma in spinal fluid specimens

In patients with a history of tobacco use or other lung cancer risk, or if thymoma is suspected, PAVAL / Paraneoplastic Autoantibody Evaluation, Serum is also recommended.

Specimen Requirements
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​CSF​Sterile Vial​4 mL​2 mL
Collection Processing Instructions

Provide the following information:

-Relevant clinical information

-Ordering provider name, phone number, mailing address, and e-mail address

Specimen Stability Information
Specimen TypeTemperatureTime
​CSF ​ ​​Refrigerated (preferred)​28 days
​Frozen​28 days
​Ambient​72 hours
Rejection Criteria
Gross hemolysis
​Gross lipemia
​Gross icterus
Performing Laboratory Information
Performing LocationDay(s) Test PerformedReport AvailableMethodology/Instrumentation
Mayo Clinic Laboratories​​Monday through Sunday​5 to 10 days

AGN1C, AMPHC, AMPIC, ANN1C, ANN2C, ANN3C, CRMC, DPPIC, DPPTC, GABIC, GL1IC, GL1TC, NMDIC, PCA1C, PCA2C, PCTRC: Indirect Immunofluorescence Assay (IFA)

CRMWC: Western Blot

AGNBC, AMIBC, AN1BC, AN2BC, PC1BC, PCTBC: Immunoblot (IB)

GD65C, VGKCC: Radioimmunoassay (RIA)

AMPCC, CS2CC, DPPCC, GABCC, GL1CC, LG1CC, NMDCC: Cell-Binding Assay (CBA)

Reference Lab
Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​See Interpretive Report
Interpretation

​Antibodies directed at onconeural proteins shared by neurons, glia, muscle, and certain cancers are valuable serological markers of a patient's immune response to cancer. They are not found in healthy subjects, and are usually accompanied by subacute neurological symptoms and signs. Several autoantibodies have a syndromic association, but no autoantibody predicts a specific neurological syndrome. Conversely, a positive autoantibody profile has 80% to 90% predictive value for a specific cancer. It is not uncommon for more than one paraneoplastic autoantibody to be detected, each predictive of the same cancer.

Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​86255​9
​84182​1​AGNBC​if appropriate
​86255​1​AMPCC​​if appropriate
​86256​1​AMPIC​​if appropriate
​84182​1​AMIBC​​if appropriate
​84182​1​AN1BC​if appropriate
​84182​1​AN2BC​if appropriate
​86255​1​CS2CC​if appropriate
​84182​1​CRMWC​if appropriate
​86255​1​DPPCC​if appropriate
​86256​1​DPPTC​if appropriate
​86255​1​DPPIC​if appropriate
​86255​1​GABCC​if appropriate
​86256​1​GABIC​if appropriate
​86341​1​GD65C​if appropriate
​86255​1​LG1CC​if appropriate
​86255​1​GL1CC​if appropriate
​86256​1​GL1TC​if appropriate
​86255​1​GL1IC​if appropriate
​86255​1​NMDCC​if appropriate
​86256​1​NMDIC​if appropriate
​84182​1​PC1BC​if appropriate
​84182​1​PCTBC​if appropriate
​83519​1​VGKCC​if appropriate
Synonyms/Keywords

​Amphiphysin Ab, CSF, ANNA-1, CSF, ANNA-2, CSF, ANNA-3, CSF, Anti-Hu, Antineuronal Cerebellar Antibodies, CRMP-5-IgG, CSF, Dorsal Root Ganglion Antibody, Hu Antibody, Neuron Restricted Autoantibodies, Neuronal Nuclear Antibody, Neuronal-Anti, Ovarian Cancer-Related Antibodies, Paraneoplastic Autoantibody Western Blot Confirmation, CSF, Paraneoplastic Neurological Autoimmunity, PCA-1, CSF, PCA-2, CSF, PCA-Tr, CSF, Purkinje Cell Cytoplasmic Antibodies, Ri, Anti, Yo-Anti

Ordering Applications
Ordering ApplicationDescription
​COM​Paraneoplastic, Autoantibody CSF (PAC1)
​Cerner​Paraneoplastic, Autoantibody Evaluation, Spinal Fluid (PAC1)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​CSF​Sterile Vial​4 mL​2 mL
Collection Processing

Provide the following information:

-Relevant clinical information

-Ordering provider name, phone number, mailing address, and e-mail address

Specimen Stability Information
Specimen TypeTemperatureTime
​CSF ​ ​​Refrigerated (preferred)​28 days
​Frozen​28 days
​Ambient​72 hours
Rejection Criteria
Gross hemolysis
​Gross lipemia
​Gross icterus
Useful For

​Aids in the diagnosis of paraneoplastic neurological autoimmune disorders related to carcinoma of lung, breast, ovary, thymoma, or Hodgkin lymphoma in spinal fluid specimens

In patients with a history of tobacco use or other lung cancer risk, or if thymoma is suspected, PAVAL / Paraneoplastic Autoantibody Evaluation, Serum is also recommended.

Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​See Interpretive Report
Interpretation

​Antibodies directed at onconeural proteins shared by neurons, glia, muscle, and certain cancers are valuable serological markers of a patient's immune response to cancer. They are not found in healthy subjects, and are usually accompanied by subacute neurological symptoms and signs. Several autoantibodies have a syndromic association, but no autoantibody predicts a specific neurological syndrome. Conversely, a positive autoantibody profile has 80% to 90% predictive value for a specific cancer. It is not uncommon for more than one paraneoplastic autoantibody to be detected, each predictive of the same cancer.

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedReport AvailableMethodology/Instrumentation
Mayo Clinic Laboratories​​Monday through Sunday​5 to 10 days

AGN1C, AMPHC, AMPIC, ANN1C, ANN2C, ANN3C, CRMC, DPPIC, DPPTC, GABIC, GL1IC, GL1TC, NMDIC, PCA1C, PCA2C, PCTRC: Indirect Immunofluorescence Assay (IFA)

CRMWC: Western Blot

AGNBC, AMIBC, AN1BC, AN2BC, PC1BC, PCTBC: Immunoblot (IB)

GD65C, VGKCC: Radioimmunoassay (RIA)

AMPCC, CS2CC, DPPCC, GABCC, GL1CC, LG1CC, NMDCC: Cell-Binding Assay (CBA)

Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​86255​9
​84182​1​AGNBC​if appropriate
​86255​1​AMPCC​​if appropriate
​86256​1​AMPIC​​if appropriate
​84182​1​AMIBC​​if appropriate
​84182​1​AN1BC​if appropriate
​84182​1​AN2BC​if appropriate
​86255​1​CS2CC​if appropriate
​84182​1​CRMWC​if appropriate
​86255​1​DPPCC​if appropriate
​86256​1​DPPTC​if appropriate
​86255​1​DPPIC​if appropriate
​86255​1​GABCC​if appropriate
​86256​1​GABIC​if appropriate
​86341​1​GD65C​if appropriate
​86255​1​LG1CC​if appropriate
​86255​1​GL1CC​if appropriate
​86256​1​GL1TC​if appropriate
​86255​1​GL1IC​if appropriate
​86255​1​NMDCC​if appropriate
​86256​1​NMDIC​if appropriate
​84182​1​PC1BC​if appropriate
​84182​1​PCTBC​if appropriate
​83519​1​VGKCC​if appropriate
For most current information refer to the Marshfield Laboratory online reference manual.