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26441 M-Protein Isotype, Matrix-Assisted Laser Desorption-Ionization Time-of-Flight Mass Spectrometry, Serum

M-Protein Isotype, Matrix-Assisted Laser Desorption-Ionization Time-of-Flight Mass Spectrometry, Serum
Test Code: MALDSO
Synonyms/Keywords

​M-Protein Isotype, Serum (MALD), Immunofixation, Immunosubtraction, Isotyping, Mass-Fix, miRAMM, Multiple Myeloma, MassFix 

Useful For

​Aiding in the diagnosis of monoclonal gammopathies, when used in conjuction with free light chain studies

This test alone is not considered an adequate screen for monoclonal gammopathies.

Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)		Pediatric Minimum Volume
(no repeat)
12 hours preferred but not required​​Serum​Serum Separator Tube (SST)​Red Top Tube (RTT)​1 mL​​
Specimen Stability Information
Specimen TypeTemperatureTime
​Serum ​ ​​Refrigerated (preferred)​28 Days
​Frozen​28 Days
​Ambient​7 Days
Interference

​No significant cautionary statements

Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
Mayo Clinic Laboratories​​Monday through Friday​2-5 Days​Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS)
Reference Lab
Mayo Clinic Laboratories
Test Information

​Immunotyping of monoclonal (M-) proteins identifies the monoclonal immunoglobulin heavy chain type (gamma, alpha, mu, delta, or epsilon) and light chain type (kappa or lambda) in serum specimens.

Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​Negative: No monoclonal protein detected.
Interpretation

​A characteristic monoclonal band (M-spike) is often found on serum protein electrophoresis (SPE) in the gamma globulin region and, more rarely, in the beta or alpha-2 regions. The finding of an M-spike, restricted migration, or hypogammaglobulinemic protein electrophoresis pattern is suggestive of a possible monoclonal protein.

Immunoaffinity purification followed by matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) is performed to identify the immunoglobulin heavy and light chains.

Outreach CPTs
CPTModifier
(if needed)		QuantityDescriptionComments
0077U​​​1​​
​86334​​1​​(if appropriate)
Synonyms/Keywords

​M-Protein Isotype, Serum (MALD), Immunofixation, Immunosubtraction, Isotyping, Mass-Fix, miRAMM, Multiple Myeloma, MassFix 

Ordering Applications
Ordering ApplicationDescription
​COM​M-Protein Isotype, Serum (MALD)
​Cerner​M-Protein Isotype, Serum
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)		Pediatric Minimum Volume
(no repeat)
12 hours preferred but not required​​Serum​Serum Separator Tube (SST)​Red Top Tube (RTT)​1 mL​​
Specimen Stability Information
Specimen TypeTemperatureTime
​Serum ​ ​​Refrigerated (preferred)​28 Days
​Frozen​28 Days
​Ambient​7 Days
Interference

​No significant cautionary statements

Useful For

​Aiding in the diagnosis of monoclonal gammopathies, when used in conjuction with free light chain studies

This test alone is not considered an adequate screen for monoclonal gammopathies.

Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​Negative: No monoclonal protein detected.
Interpretation

​A characteristic monoclonal band (M-spike) is often found on serum protein electrophoresis (SPE) in the gamma globulin region and, more rarely, in the beta or alpha-2 regions. The finding of an M-spike, restricted migration, or hypogammaglobulinemic protein electrophoresis pattern is suggestive of a possible monoclonal protein.

Immunoaffinity purification followed by matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) is performed to identify the immunoglobulin heavy and light chains.

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
Mayo Clinic Laboratories​​Monday through Friday​2-5 Days​Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS)
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)		QuantityDescriptionComments
0077U​​​1​​
​86334​​1​​(if appropriate)
For most current information refer to the Marshfield Laboratory online reference manual.