CATR, Cold Agglutinin Titer, Cryoagglutinin
Detection of cold agglutinins in patients with suspected cold agglutinin disease.
1. Use a warm pack to keep specimen at 37 degrees C prior to and after collecting.
2. Allow specimens to clot at 37 degrees C.
3. Centrifuge at 37 degrees C and separate serum from red cells immediately after blood clots, or within one hour of collection.
4. Do not refrigerate prior to separation of serum from red cells.
Normal individuals may have low levels of cold agglutinins.
Patients with cold agglutinin syndrome usually exhibit a titer value greater than 1:512, with rare cases reportedly as low as 1:64.
Normal individuals often have low levels of cold agglutinins.
The test is not a direct measure of clinical significance and must be used in conjunction with other in vitro and in vivo parameters.