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26303 Ethyl Glucuronide, Urine

Ethyl Glucuronide, Urine
Test Code: ETG
Synonyms/Keywords

​Ethyl Glucuronide, Ethyl Sulfate

Test Components

This is a confirmatory test done by LCMSMS methodology to definitively detect and quantitate ethyl glucuronide and ethyl sulfate in urine.

Useful For

This test will detect previous alcohol use for a longer period of time after ingestion than a traditional test for ethanol.

Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No​Urine​Sage urine collection container​Plastic container with no preservatives​5 mL​2 mL​1 mL
Specimen Stability Information
Specimen TypeTemperatureTime
​Urine ​ ​​Ambient​72 hours
​Refrigerated (preferred)​14 days
​Frozen​14 days
Rejection Criteria
Urine received in preservative.
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Marshfield Toxicology​Monday-Friday 8 am​2 - 4 days​Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring
Test Information

Ethanol as a recreational and social drug has been ingested by the human species for millennia.  With its use comes the risk of addiction, due to genetic, mental, physical, and/or situational factors.  In cases of abuse, individuals may refer to rehabilitation programs to receive support and help to quit using.  Often a "no tolerance" policy may be enforced as part of the treatment.  Random urine spot checks ensure compliance.

Ethanol analyte testing works well for recent ingestion (under 12 h); however, rehabilitation stays can easily exceed this window.  A metabolite that remains in the body for an extended period of time (1-3 days) is ideal for monitoring a multi-day treatment cycle.

This assay instead analyzes the minor metabolites of ethanol: ethyl sulfate and ethyl glucuronide.  The trace concentrations found in the body after ethanol ingestion are ideal for analysis by ultra high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS).  The levels found in urine, as well as the window of excretion (typically at least a day from as little as a 1 oz drink) are quite similar to drugs of abuse, and thus can be reported and interpreted in a similar manner.

Reference Range Information
Performing LocationReference Range
​MarshfieldNegative; Positives are reported with a quantitative result for ethyl glucuronide and/or ethyl sulfate
Interpretation

Typically, detection time lasts from a few hours after ingestion through 3 days, but may vary with weight, age, metabolism, and tolerance.

 Current Cutoff Levels for Toxicology

Outreach CPTs
CPTModifier
(if needed)
QuantityDescription

Comments

​80321Alcohol Metabolites, Quantitative, Urine ​​
​G0480Drug test(s), definitive, utilizing drug identification methods able to identify individual drugs and distinguish between structural isomers per day, 1-7 drug class(es), including metabolite(s) if performed.​​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.

Synonyms/Keywords

​Ethyl Glucuronide, Ethyl Sulfate

Test Components

This is a confirmatory test done by LCMSMS methodology to definitively detect and quantitate ethyl glucuronide and ethyl sulfate in urine.

Ordering Applications
Ordering ApplicationDescription
​COMEthyl Glucuronide, Urine
​CernerEthyl Glucuronide, Urine
​PortalEthyl Glucuronide, Urine
​CentricityEthyl Glucuronide, Urine
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting RequiredSpecimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​No​Urine​Sage urine collection container​Plastic container with no preservatives​5 mL​2 mL​1 mL
Specimen Stability Information
Specimen TypeTemperatureTime
​Urine ​ ​​Ambient​72 hours
​Refrigerated (preferred)​14 days
​Frozen​14 days
Rejection Criteria
Urine received in preservative.
Useful For

This test will detect previous alcohol use for a longer period of time after ingestion than a traditional test for ethanol.

Test Components

This is a confirmatory test done by LCMSMS methodology to definitively detect and quantitate ethyl glucuronide and ethyl sulfate in urine.

Reference Range Information
Performing LocationReference Range
​MarshfieldNegative; Positives are reported with a quantitative result for ethyl glucuronide and/or ethyl sulfate
Interpretation

Typically, detection time lasts from a few hours after ingestion through 3 days, but may vary with weight, age, metabolism, and tolerance.

 Current Cutoff Levels for Toxicology

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Marshfield Toxicology​Monday-Friday 8 am​2 - 4 days​Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)
QuantityDescription

Comments

​80321Alcohol Metabolites, Quantitative, Urine ​​
​G0480Drug test(s), definitive, utilizing drug identification methods able to identify individual drugs and distinguish between structural isomers per day, 1-7 drug class(es), including metabolite(s) if performed.​​For Medicare/Medicaid
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.

For most current information refer to the Marshfield Laboratory online reference manual.