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26207 2,3-Dinor-11Beta-Prostaglandin F2 Alpha, Urine (23BPG)

2,3-Dinor-11Beta-Prostaglandin F2 Alpha, Urine (23BPG)
Test Code: 23BPGSO
Synonyms/Keywords

​2,3 11 Beta-Prostaglandin F2 Alpha
Prostaglandin
Mastocytosis
23BPG
11BPG
BPG2
11 Beta-Prostaglandin F2 Alpha

Useful For

​Screening for mast cell activation disorders including systemic mastocytosis

Specimen Requirements
​Submit only 1 of the following specimens:  ​ ​
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Urine, 24-hour24-hour Urine Jug​4 mL​3 mL
Urine, Random​Sterile Container​4 mL​3 mL
Collection Processing Instructions

​For 24-hour Urine Collection:

1. Collect urine for 24 hours.

2. Refrigerate specimen during collection, and send specimen refrigerated.

 

For Random Urine Collection: 

1. Collect a random urine specimen. 

2. Refrigerate specimen after collection. Send specimen refrigerated or frozen; do not add any preservative.

Patient Preparation: Patients taking aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) may have decreased concentrations of prostaglandin F2 alpha. If possible, discontinue for 2 weeks or 72 hours, respectively, prior to collecting a specimen.

Specimen Stability Information
Specimen TypeTemperatureTime
​Urine ​ ​​Refrigerated (preferred)​14 days
​Frozen​30 days
​Ambient​8 hours
Rejection Criteria
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability. 
Interference

​Elevated levels of 2,3-dinor-11beta-prostaglandin F2 alpha (2,3 BPG) in urine are not specific for systemic mast cell disease and may be found in patients with angioedema, diffuse urticaria, or myeloproliferative diseases in the absence of diffuse mast cell proliferation. 

Systemic mast cell disease is a heterogeneous disease, and some patients may not have elevated (2,3 BPG)  in urine.

Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Mayo Clinic Laboratories​Monday, Thursday​2 days

23BPG: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

AACT: Enzymatic Colorimetric Assay

Reference Lab
Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​<5,205 pg/mg creatinine
Interpretation

​Urinary 2,3-dinor-11beta-prostaglandin F2 alpha (2,3-BPG) values above 3,263 pg/mg creatinine are consistent with, but not necessarily diagnostic of, systemic mastocytosis. Values should be interpreted in the context of clinical presentation and additional mast cell disease markers (serum tryptase, urinary N-methyl histamine, and/or urinary leukotriene E4).

Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​84150​1
Synonyms/Keywords

​2,3 11 Beta-Prostaglandin F2 Alpha
Prostaglandin
Mastocytosis
23BPG
11BPG
BPG2
11 Beta-Prostaglandin F2 Alpha

Ordering Applications
Ordering ApplicationDescription
​COM​2,3Dinor11-BProstagl F2, U
​Cerner​2,3 Dinor B-Prostaglan (23BPG)
​Centricity​2,3 Dinor B-Prostaglan (23BPG)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
​Submit only 1 of the following specimens:  ​ ​
Specimen TypePreferred Container/TubeAcceptable Container/TubeSpecimen VolumeSpecimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Urine, 24-hour24-hour Urine Jug​4 mL​3 mL
Urine, Random​Sterile Container​4 mL​3 mL
Collection Processing

​For 24-hour Urine Collection:

1. Collect urine for 24 hours.

2. Refrigerate specimen during collection, and send specimen refrigerated.

 

For Random Urine Collection: 

1. Collect a random urine specimen. 

2. Refrigerate specimen after collection. Send specimen refrigerated or frozen; do not add any preservative.

Patient Preparation: Patients taking aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) may have decreased concentrations of prostaglandin F2 alpha. If possible, discontinue for 2 weeks or 72 hours, respectively, prior to collecting a specimen.

Specimen Stability Information
Specimen TypeTemperatureTime
​Urine ​ ​​Refrigerated (preferred)​14 days
​Frozen​30 days
​Ambient​8 hours
Rejection Criteria
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability. 
Interference

​Elevated levels of 2,3-dinor-11beta-prostaglandin F2 alpha (2,3 BPG) in urine are not specific for systemic mast cell disease and may be found in patients with angioedema, diffuse urticaria, or myeloproliferative diseases in the absence of diffuse mast cell proliferation. 

Systemic mast cell disease is a heterogeneous disease, and some patients may not have elevated (2,3 BPG)  in urine.

Useful For

​Screening for mast cell activation disorders including systemic mastocytosis

Reference Range Information
Performing LocationReference Range
​Mayo Clinic Laboratories​<5,205 pg/mg creatinine
Interpretation

​Urinary 2,3-dinor-11beta-prostaglandin F2 alpha (2,3-BPG) values above 3,263 pg/mg creatinine are consistent with, but not necessarily diagnostic of, systemic mastocytosis. Values should be interpreted in the context of clinical presentation and additional mast cell disease markers (serum tryptase, urinary N-methyl histamine, and/or urinary leukotriene E4).

For more information visit:
Performing Laboratory Information
Performing LocationDay(s) Test PerformedAnalytical TimeMethodology/Instrumentation
​Mayo Clinic Laboratories​Monday, Thursday​2 days

23BPG: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

AACT: Enzymatic Colorimetric Assay

Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPTModifier
(if needed)
QuantityDescriptionComments
​84150​1
For most current information refer to the Marshfield Laboratory online reference manual.