Centrifuge and separate plasma from cells within 4 hours of collection.
Fill out the following form: Biochemical Genetics Patient Information
Factors that may influence and increase plasma homocysteine include:
-Poor diet/cofactor deficiencies
-Chronic kidney disease/renal disease
Medications that may increase homocysteine concentrations include:
Elevated homocysteine concentrations are considered infomative in patients evaluated for suspected nutritional deficiencies (vitamin B12, foltate) and inborn errors of metabolism. Measurement of methylmalonic acid (MMA) distinguishes between B12 (cobalamin) and folate deficiencies, as MMA is only elevated in vitamin B12 deficiency. Treatment response can be evaluated by monitoring plasma homocysteine concentrations over time.