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MyoMarker Panel 3 (FMP3)
Test Code: FMP3SO
Synonyms/Keywords
PL-7, PL-12, EJ, OJ, SRP, MI-2, Fibrillarin (U3 RNP), U2 snRNP, Ku, Anti-Jo-1 Ab, TIF1 GAMMA (P155/140), MDA-5 (P140) (CADM-140), NXP-2 (P140), Anti-PM/Scl-100 Ab, Anti-U1-RNP Ab, Anti-SS-A 52 kD Ab IgG, Anti-SAE 1 IgG
Test Components
PL-7, PL-12, EJ, OJ, SRP, MI-2, Fibrillarin (U3 RNP), U2 snRNP, Ku, Anti-Jo-1 Ab, TIF1 GAMMA (P155/140), MDA-5 (P140) (CADM-140), NXP-2 (P140), Anti-PM/Scl-100 Ab, Anti-U1-RNP Ab, Anti-SS-A 52 kD Ab IgG, Anti-SAE 1 IgG
Useful For

Anti-Jo 1 Abs are found in subset of myositis patients characterized by interstitial lung disease, systemic polyarthritis, Raynaud's Phenomena, fever and Mechanic's Hand (anti-synthetase syndrome).

Anti-Jo 1 appears to be a marker for interstitial lung disease in polymyositis.

The anti-PM/Scl-100 antibody is associated with younger age, calcinosis and has lower rates of gastrointestinal symptoms, ILD and pulmonary hypertension. There is also evidence of a possibly better survival compared to the presence of either anti-PM/Scl-75 or anti-Scl-70 antibodies.

Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Submit only 1 of the following specimens: ​ ​ ​ ​ ​ ​ ​
​No ​Serum ​Serum Red Top Tube (RTT) ​Serum Separator Tube (SST) ​3 mL ​1 mL
​No ​Plasma ​EDTA Lavender Top Tube (LTT) ​3 mL ​1 mL
Collection Processing Instructions
Draw blood in appropriate tube. Spin down and send 3 mL refrigerated in a plastic vial.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​Refrigerate (preferred) ​60 days
​Frozen ​14 days
​Ambient ​7 days
​Plasma ​ ​ ​Refrigerate (preferred) ​60 days
​Frozen ​14 days
​Ambient ​7 days
Rejection Criteria
Gross Hemolysis
​Gross Icterus
​Gross Lipema
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Labs ​Batched Weekly ​10-18 days ​RIPA, EIA
Reference Lab
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Labs PL-7, PL-12, EJ, OJ, SRP, MI-2, Fibrillarin (U3 RNP), U2 snRNP, Ku:
Reference Range:          Negative
Anti-Jo-1 Ab, TIF1 GAMMA (P155/140), MDA-5 (P140) (CADM-140), NXP-2 (P140), Anti-PM/Scl-100 Ab, Anti-U1-RNP Ab, Anti-SS-A 52 kD Ab IgG:
Reference Range:          <20
EIA Interpretation:      
Negative:                      <20 units
Weak Positive:              20 – 39 units
Moderate Positive:        40 – 80 units
Strong Positive:            >80 units
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​83615 ​9 ​Anti-PL-12 Ab, Anti-PL-7 Ab, Anti-EJ Ab, Anti-OJ Ab , Anti-SRP Ab, Anti-Ku Ab, Anti-MDA5 Ab, Anti-NXP2 Ab, Anti-TIF-1? Ab
​86235 ​7 ​Anti-U2 RNP, Anti-PM/Scl-100 Ab, Anti-SSA 52 kD IgG Ab, Anti-U1 RNP Ab, Anti-Fibrillarin U3 RNP Ab, Anti-Jo-1 Ab, Anti-Mi-2 Ab
Synonyms/Keywords
PL-7, PL-12, EJ, OJ, SRP, MI-2, Fibrillarin (U3 RNP), U2 snRNP, Ku, Anti-Jo-1 Ab, TIF1 GAMMA (P155/140), MDA-5 (P140) (CADM-140), NXP-2 (P140), Anti-PM/Scl-100 Ab, Anti-U1-RNP Ab, Anti-SS-A 52 kD Ab IgG, Anti-SAE 1 IgG
Test Components
PL-7, PL-12, EJ, OJ, SRP, MI-2, Fibrillarin (U3 RNP), U2 snRNP, Ku, Anti-Jo-1 Ab, TIF1 GAMMA (P155/140), MDA-5 (P140) (CADM-140), NXP-2 (P140), Anti-PM/Scl-100 Ab, Anti-U1-RNP Ab, Anti-SS-A 52 kD Ab IgG, Anti-SAE 1 IgG
Ordering Applications
Ordering Application Description
​Centricity ​MyoMarker Panel 3 (FMP3)
​Cerner ​MyoMarker Panel 3 (FMP3)
​COM ​MyoMarker Panel 3 (FMP3)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Submit only 1 of the following specimens: ​ ​ ​ ​ ​ ​ ​
​No ​Serum ​Serum Red Top Tube (RTT) ​Serum Separator Tube (SST) ​3 mL ​1 mL
​No ​Plasma ​EDTA Lavender Top Tube (LTT) ​3 mL ​1 mL
Collection Processing Instructions
Draw blood in appropriate tube. Spin down and send 3 mL refrigerated in a plastic vial.
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​ ​Refrigerate (preferred) ​60 days
​Frozen ​14 days
​Ambient ​7 days
​Plasma ​ ​ ​Refrigerate (preferred) ​60 days
​Frozen ​14 days
​Ambient ​7 days
Rejection Criteria
Gross Hemolysis
​Gross Icterus
​Gross Lipema
Useful For

Anti-Jo 1 Abs are found in subset of myositis patients characterized by interstitial lung disease, systemic polyarthritis, Raynaud's Phenomena, fever and Mechanic's Hand (anti-synthetase syndrome).

Anti-Jo 1 appears to be a marker for interstitial lung disease in polymyositis.

The anti-PM/Scl-100 antibody is associated with younger age, calcinosis and has lower rates of gastrointestinal symptoms, ILD and pulmonary hypertension. There is also evidence of a possibly better survival compared to the presence of either anti-PM/Scl-75 or anti-Scl-70 antibodies.

Reference Range Information
Performing Location Reference Range
​Mayo Clinic Labs PL-7, PL-12, EJ, OJ, SRP, MI-2, Fibrillarin (U3 RNP), U2 snRNP, Ku:
Reference Range:          Negative
Anti-Jo-1 Ab, TIF1 GAMMA (P155/140), MDA-5 (P140) (CADM-140), NXP-2 (P140), Anti-PM/Scl-100 Ab, Anti-U1-RNP Ab, Anti-SS-A 52 kD Ab IgG:
Reference Range:          <20
EIA Interpretation:      
Negative:                      <20 units
Weak Positive:              20 – 39 units
Moderate Positive:        40 – 80 units
Strong Positive:            >80 units
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Labs ​Batched Weekly ​10-18 days ​RIPA, EIA
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​83615 ​9 ​Anti-PL-12 Ab, Anti-PL-7 Ab, Anti-EJ Ab, Anti-OJ Ab , Anti-SRP Ab, Anti-Ku Ab, Anti-MDA5 Ab, Anti-NXP2 Ab, Anti-TIF-1? Ab
​86235 ​7 ​Anti-U2 RNP, Anti-PM/Scl-100 Ab, Anti-SSA 52 kD IgG Ab, Anti-U1 RNP Ab, Anti-Fibrillarin U3 RNP Ab, Anti-Jo-1 Ab, Anti-Mi-2 Ab
For most current information refer to the Marshfield Laboratory online reference manual.