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26019 Phospholipase A2 Recpt (PLA2R)

Phospholipase A2 Recpt (PLA2R)
Test Code: PLA2RSO
Synonyms/Keywords
PLA2R, Anti-PLA2R
Useful For
Distinguishing primary from secondary membranous nephropathy
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Serum ​Serum Separator Tube (SST) ​1 mL ​0.5 mL
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Refrigerate (preferred) ​14 days
​Frozen ​14 days
​Room Temperature ​8 hours
Rejection Criteria
Gross Hemolysis
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories ​Monday, Wednesday, Friday ​3 days

​EURO: Enzyme-Linked Immunosorbent Assay (ELISA)

SCOPE: Indirect Immunofluorescence Assay (IFA)

Reference Lab
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories

ELISA: Negative: <14 RU/mL

Borderline: > or =14-<20 RU/mL

Positive: > or =20 RU/mL 

 

IFA: Negative

Interpretation
Therapy outcome can be monitored by measuring the anti-phospholipase A2 receptor (PLA2R) antibody titer. A titer increase, decrease, or disappearance generally precedes a change in clinical status. Thus, the determination of the antibody titer has a high predictive value with respect to clinical remission, relapse, or risk assessment after kidney transplantation.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
83520 ​1 ​Fluorescent Antibody Titer
​86255 ​1 ​Fluorescent Antibody Screen
Synonyms/Keywords
PLA2R, Anti-PLA2R
Ordering Applications
Ordering Application Description
​COM ​Phospholipase A2 Recpt (PLA2R)
​Centricity ​Phospholipase A2 Recpt (PLA2R)
​Cerner ​Phospholipase A2 Recpt (PLA2R)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Serum ​Serum Separator Tube (SST) ​1 mL ​0.5 mL
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Refrigerate (preferred) ​14 days
​Frozen ​14 days
​Room Temperature ​8 hours
Rejection Criteria
Gross Hemolysis
Useful For
Distinguishing primary from secondary membranous nephropathy
Reference Range Information
Performing Location Reference Range
​Mayo Clinic Laboratories

ELISA: Negative: <14 RU/mL

Borderline: > or =14-<20 RU/mL

Positive: > or =20 RU/mL 

 

IFA: Negative

Interpretation
Therapy outcome can be monitored by measuring the anti-phospholipase A2 receptor (PLA2R) antibody titer. A titer increase, decrease, or disappearance generally precedes a change in clinical status. Thus, the determination of the antibody titer has a high predictive value with respect to clinical remission, relapse, or risk assessment after kidney transplantation.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories ​Monday, Wednesday, Friday ​3 days

​EURO: Enzyme-Linked Immunosorbent Assay (ELISA)

SCOPE: Indirect Immunofluorescence Assay (IFA)

Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
83520 ​1 ​Fluorescent Antibody Titer
​86255 ​1 ​Fluorescent Antibody Screen
For most current information refer to the Marshfield Laboratory online reference manual.