Skip Ribbon Commands
Skip to main content
Sign In
Navigate Up

25302 Liver-Kidney-Microsome-1 Antibodies, IgG

Liver-Kidney-Microsome-1 Antibodies, IgG
Test Code: LKM1
Synonyms/Keywords
​LKM, LKM1, Autoimmune hepatitis type 2
Useful For
Useful in the diagnosis of autoimmune hepatitis (AIH).  Type 2 AIH is characterized by the presence of LKM-1 antibodies, in the absence of antinuclear antibody (ANA), smooth muscle antibody, or soluble liver antigen (SLA) antibody.  The major target antigen of LKM-1 antibodies has been identified as cytochrome P450 2D6, a microsomal protein found in the endoplasmic reticulum.  LKM-1 antibodies may be detected in a subset of patients with chronic hepatitis C.  Definitive diagnosis of type 2 AIH should be based on the correlation of all available clinical, biochemical, and liver biopsy information.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Serum Red Top Tube (RTT) ​Serum Separator Tube (SST) 1.0 mL 0.5 mL 0.5 mL
Collection Processing Instructions

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
​ ​Serum ​ ​ ​Ambient ​8 hours
Refrigerate at 2-8 deg Celsius 2 days
Frozen at -20 deg Celsius ​>2 days
Rejection Criteria

Gross Lipemia

​Gross Hemolysis

​Heat inactivated samples
​Microbially contaminated samples
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Thursday​​
 ​1-2 days ​Enzyme Immunoassay
Test Information
Testing is performed on Thursday. The magnitude of the reported LKM-1 IgG EIA level cannot be correlated to an endpoint titer.
Reference Range Information
Performing Location Reference Range
​Marshfield ​ ​ ​<= 20.0 Units Negative
​20.1-24.9 Units Equivocal
​>= 25.0 Units Positive
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86376 ​ ​ ​ ​
Synonyms/Keywords
​LKM, LKM1, Autoimmune hepatitis type 2
Ordering Applications
Ordering Application Description

​Cerner
​Liver-Kidney-Microsomal-1 Antibodies, IgG
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
​No ​Serum Red Top Tube (RTT) ​Serum Separator Tube (SST) 1.0 mL 0.5 mL 0.5 mL
Collection Processing

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
​ ​Serum ​ ​ ​Ambient ​8 hours
Refrigerate at 2-8 deg Celsius 2 days
Frozen at -20 deg Celsius ​>2 days
Rejection Criteria

Gross Lipemia

​Gross Hemolysis

​Heat inactivated samples
​Microbially contaminated samples
Useful For
Useful in the diagnosis of autoimmune hepatitis (AIH).  Type 2 AIH is characterized by the presence of LKM-1 antibodies, in the absence of antinuclear antibody (ANA), smooth muscle antibody, or soluble liver antigen (SLA) antibody.  The major target antigen of LKM-1 antibodies has been identified as cytochrome P450 2D6, a microsomal protein found in the endoplasmic reticulum.  LKM-1 antibodies may be detected in a subset of patients with chronic hepatitis C.  Definitive diagnosis of type 2 AIH should be based on the correlation of all available clinical, biochemical, and liver biopsy information.
Reference Range Information
Performing Location Reference Range
​Marshfield ​ ​ ​<= 20.0 Units Negative
​20.1-24.9 Units Equivocal
​>= 25.0 Units Positive
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Thursday​​
 ​1-2 days ​Enzyme Immunoassay
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
​86376 ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.