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25240 Pipecolic Acid, Serum (PIPA)

Pipecolic Acid, Serum (PIPA)
Test Code: PIPASO
Useful For

​Differential diagnosis between disorders of peroxisomal biogenesis (eg., Zellweger syndrome) and disorders with loss of a single peroxisomal function.

Detecting abnormal elevations of pipecolic acid in serum

Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​YES-12 hour fast or prior to next feeding for infants/small children ​Serum ​Red Top Tube (RTT) ​Serum Separatory Tube (SST) ​1.5 mL ​1.0 mL
Collection Processing Instructions
​Patient's age is required
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Frozen (preferred) ​94 days
​Refrigerated​14 days
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories Tuseday ​2 days ​Gas Chromatography-Mass Spectrometry (GC-MS)
Reference Lab
Reference Range Information

<6 months: < or = 6.0 nmol/mL

6 months- <1 year: < or = 5.9 nmol/mL

1-17 years: < or = 4.3 nmol/mL

> or = 18 years: < or = 7.4 nmol/mL

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
82542
Ordering Applications
Ordering Application Description
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​YES-12 hour fast or prior to next feeding for infants/small children ​Serum ​Red Top Tube (RTT) ​Serum Separatory Tube (SST) ​1.5 mL ​1.0 mL
Collection Processing
​Patient's age is required
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Frozen (preferred) ​94 days
​Refrigerated​14 days
Useful For

​Differential diagnosis between disorders of peroxisomal biogenesis (eg., Zellweger syndrome) and disorders with loss of a single peroxisomal function.

Detecting abnormal elevations of pipecolic acid in serum

Reference Range Information

<6 months: < or = 6.0 nmol/mL

6 months- <1 year: < or = 5.9 nmol/mL

1-17 years: < or = 4.3 nmol/mL

> or = 18 years: < or = 7.4 nmol/mL

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Mayo Clinic Laboratories Tuseday ​2 days ​Gas Chromatography-Mass Spectrometry (GC-MS)
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
82542
For most current information refer to the Marshfield Laboratory online reference manual.