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25152 Buprenorphine, Urine

Buprenorphine, Urine
Test Code: BUP
Synonyms/Keywords
Buprenex, Suboxone, Subutex, Temgesic​
Useful For
Detecting exposure to buprenorphine to monitor compliance in taking prescribed medications or to detect abuse. 
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 7 mL 5 mL​ 3 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Refrigerate (Preferred)​ 14 days​
Ambient​ 14 days​
Frozen​ 14 days​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​
If no confirmatory work is required:
1 day​
 
If confirmatory work is required: 4 days
 Beckman AU680 Clinical Chemistry System with Emit Immunoassay and Liquid Chromatography/Time of Flight (LC-MS-QToF) or Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) using Multiple Reaction Monitoring (if needed for confirmation)
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.


This test is a screen for Buprenorphone by immunoassay; if the screen is positive, this test automatically includes mass-spectrometry method quantitative confirmation for buprenorphine and its metabolite, norbuprenorphine. Quantitation/confirmation charged separately if needed.  It is intended for use only in patients where an initial drug screening test has not already been performed (i.e. Point-of-Care drug screening cup, dipstick, etc.). 

Buprenorphine is a member of the opioid family and is used as an alternative to methadone in the treatment of heroin addiction and as an analgesic for treatment of moderate to severe pain.  Buprenorphine is metabolized to norbuprenorphine.  Measurement of buprenorphine and norbuprenorphine assist the clinician in determining patient compliance with treatment.

Reference Range Information
Performing Location Reference Range
Marshfield​

Negative.  Positives are reported with a quantitative LC-MS-QToF or LC-MS/MS result.

Interpretation

Current Cutoff Levels for Toxicology

​Measurement of buprenorphine and norbuprenorphine assist the clinician in determining patient compliance with treatment.  Presence of the metabolite insures actual administration of the parent drug, however, quantitation of neither can be used to determine time or amount of dosage.  No therapeutic ranges are established for the compounds in urine.

Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80307 ​ 1​ Single drug class​ ​
80348 ​ 1​ Buprenorphine Confirmation by LCMS ​If needed
​G0480 ​ ​1 ​Buprenorphine Confirmation by LCMS ​For Medicare/Medicaid, If needed
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Synonyms/Keywords
Buprenex, Suboxone, Subutex, Temgesic​
Ordering Applications
Ordering Application Description
​Cerner Buprenorphine, Urine​
​COM ​Buprenorphine, Urine
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 7 mL 5 mL​ 3 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Refrigerate (Preferred)​ 14 days​
Ambient​ 14 days​
Frozen​ 14 days​
Useful For
Detecting exposure to buprenorphine to monitor compliance in taking prescribed medications or to detect abuse. 
Reference Range Information
Performing Location Reference Range
Marshfield​

Negative.  Positives are reported with a quantitative LC-MS-QToF or LC-MS/MS result.

Interpretation

Current Cutoff Levels for Toxicology

​Measurement of buprenorphine and norbuprenorphine assist the clinician in determining patient compliance with treatment.  Presence of the metabolite insures actual administration of the parent drug, however, quantitation of neither can be used to determine time or amount of dosage.  No therapeutic ranges are established for the compounds in urine.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​
If no confirmatory work is required:
1 day​
 
If confirmatory work is required: 4 days
 Beckman AU680 Clinical Chemistry System with Emit Immunoassay and Liquid Chromatography/Time of Flight (LC-MS-QToF) or Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) using Multiple Reaction Monitoring (if needed for confirmation)
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
80307 ​ 1​ Single drug class​ ​
80348 ​ 1​ Buprenorphine Confirmation by LCMS ​If needed
​G0480 ​ ​1 ​Buprenorphine Confirmation by LCMS ​For Medicare/Medicaid, If needed
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
For most current information refer to the Marshfield Laboratory online reference manual.