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25137 MaterniT21 Plus

MaterniT21 Plus
Test Code: MAT21SO
Synonyms/Keywords
Trisomy 21, Trisomy 18, Trisomy 13​
Test Components
Analyzes the relative amount of 21, 18, 13, and Y chromosomal material in circulating cell-free DNA from a maternal blood sample.​
Useful For

Pregnant women with increased risk for chromosomal aneuploidy, including one or more of the following: Advanced maternal age, personal/family history of chromosomal abnormalities, fetal ultrasound abnormality suggestive of aneuploidy and/or positive serum screening test.

Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Whole Blood​ Special collection tube included in Materni T21 kit​ 10 mL​
Collection Processing Instructions

​Contact Lab Specimen Processing at 715-221-6220 or 800-222-5835 to obtain special collection kit and consent form. Form must be signed by both the patient and the clinician.  The sample must be room temperature, ship overnight for Monday-Saturday delivery. 

Patient/Provider signature is required.  If this is not obtained prior to sample collection, the sample will be sent out, but results will not be available until the required signatures are obtained.

THIS IS NOT AVAILABLE TO OUTREACH CLIENTS. Outreach clients must work directly with Sequenom Lab.

Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood ​Ambient 7 days
Rejection Criteria
Refrigerated and frozen samples are not acceptable ​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation

Sequenom Center for Molecular

Medicine​

Monday through Friday​ 3-5 days ​DNA extraction
Reference Range Information
Performing Location Reference Range

Sequenom Center for Molecular

Medicine​

Interpretive Report​
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​81420
Synonyms/Keywords
Trisomy 21, Trisomy 18, Trisomy 13​
Test Components
Analyzes the relative amount of 21, 18, 13, and Y chromosomal material in circulating cell-free DNA from a maternal blood sample.​
Ordering Applications
Ordering Application Description
​Centricity ​Materni T21 Plus (SJH & SCH Only)
​Cerner ​None
​Clinical Order Manager ​Materni T21 Plus
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Whole Blood​ Special collection tube included in Materni T21 kit​ 10 mL​
Collection Processing

​Contact Lab Specimen Processing at 715-221-6220 or 800-222-5835 to obtain special collection kit and consent form. Form must be signed by both the patient and the clinician.  The sample must be room temperature, ship overnight for Monday-Saturday delivery. 

Patient/Provider signature is required.  If this is not obtained prior to sample collection, the sample will be sent out, but results will not be available until the required signatures are obtained.

THIS IS NOT AVAILABLE TO OUTREACH CLIENTS. Outreach clients must work directly with Sequenom Lab.

Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood ​Ambient 7 days
Rejection Criteria
Refrigerated and frozen samples are not acceptable ​
Useful For

Pregnant women with increased risk for chromosomal aneuploidy, including one or more of the following: Advanced maternal age, personal/family history of chromosomal abnormalities, fetal ultrasound abnormality suggestive of aneuploidy and/or positive serum screening test.

Test Components
Analyzes the relative amount of 21, 18, 13, and Y chromosomal material in circulating cell-free DNA from a maternal blood sample.​
Reference Range Information
Performing Location Reference Range

Sequenom Center for Molecular

Medicine​

Interpretive Report​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation

Sequenom Center for Molecular

Medicine​

Monday through Friday​ 3-5 days ​DNA extraction
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​81420
For most current information refer to the Marshfield Laboratory online reference manual.