Elevations of dermatan sulfate and/or heparan sulfate and/or keratan sulfate and/or chondroitin-6-sulfate may be indicative of one of the mucopolysaccharidoses: types I, II, III, IV, VI, or VII.
Elevations of any or all sulfate species may be indicative of multiple sulfatase deficiency or mucolipidosisII/III.
Rarely, an elevation of keratan sulfate may be indicative of alpha-fucosidosis.