Skip Ribbon Commands
Skip to main content
Sign In

24708 TPMT Genetics, Prometheus (3300)

TPMT Genetics, Prometheus (3300)
Test Code: PTPMTSO
Synonyms/Keywords
​TPMT (thiopurine methyltransferase enzyme) Genetics
Useful For

Genotypes a patient to aid in individualizing a starting dose of thiopurines. Ordering prior to initiating therapy provides information for effective dosing, which may achieve maximum efficacy with minimized toxicity.​

Prometheus TPMT Genetics helps classify patients as one of three genotypes (homozygous normal, heterozygous, or homozygous recessive). Because each patient metabolizes thiopurines differently, the efficacy and toxicity of thiopurines can vary widely from patient to patient. Knowledge of the TPMT genotype may reduce time to response, allow physicians to individualize dosing, identify patients in whom thiopurine therapy should be avoided and help reduce the risk of leukopenia.

Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Whole Blood ​EDTA Lavender Top Tube (LTT) ​2 mL
Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood ​ ​Ambient ​10 days
​Refrigerated ​30 days
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Prometheus Labs ​Monday through Friday ​4 days ​Nucleic acid probe
Reference Lab
Reference Range Information
Performing Location Reference Range
Prometheus Labs​ ​TPMT*1/TPMT*1 - Alleles present are associated with Normal Enzyme Activity.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​81335
Synonyms/Keywords
​TPMT (thiopurine methyltransferase enzyme) Genetics
Ordering Applications
Ordering Application Description
​Centricity ​TPMT Genetics, Prometheus (3300)
​Cerner ​TPMT Genetics, Prometheus (3300)
​COM ​TPMT Genetics, Prome (3300)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Whole Blood ​EDTA Lavender Top Tube (LTT) ​2 mL
Specimen Stability Information
Specimen Type Temperature Time
​Whole Blood ​ ​Ambient ​10 days
​Refrigerated ​30 days
Useful For

Genotypes a patient to aid in individualizing a starting dose of thiopurines. Ordering prior to initiating therapy provides information for effective dosing, which may achieve maximum efficacy with minimized toxicity.​

Prometheus TPMT Genetics helps classify patients as one of three genotypes (homozygous normal, heterozygous, or homozygous recessive). Because each patient metabolizes thiopurines differently, the efficacy and toxicity of thiopurines can vary widely from patient to patient. Knowledge of the TPMT genotype may reduce time to response, allow physicians to individualize dosing, identify patients in whom thiopurine therapy should be avoided and help reduce the risk of leukopenia.

Reference Range Information
Performing Location Reference Range
Prometheus Labs​ ​TPMT*1/TPMT*1 - Alleles present are associated with Normal Enzyme Activity.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Prometheus Labs ​Monday through Friday ​4 days ​Nucleic acid probe
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​81335
For most current information refer to the Marshfield Laboratory online reference manual.