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Lab Test Reference Manual
Human Reference Manual
Pages
23035
Lab Test Reference Manual
Human Reference Manual
Currently selected
23035
Zinc Protoporphyrin (NEZPP)
Marshfield Lab Public WebSite
Marshfield Clinic Public WebSite
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Site Contents
Zinc Protoporphyrin (NEZPP)
Test Code: ZPPSO
Overview
Ordering
Specimen
Performing
Clinical/Interpretive
Contacts
Coding
Synonyms/Keywords
Synonyms, Keywords
Protoporphyrin, Zinc, Zinc Protoporphyrin
Useful For
Useful For
Evaluating iron deficiency
Monitoring treatment and environmental intervention of chronic lead poisoning
Specimen Requirements
Specimen Requirements
Specimen Type
Preferred Container/Tube
Acceptable Container/Tube
Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Whole blood
Royal blue-top Monoject trace element blood collection tube, containing EDTA as an anticoagulant (RBTT)
1 mL
0.3 mL
Collection Processing Instructions
Collection Processing
See Mayo's
Lead/Heavy Metals Reporting Form.
Specimen Stability Information
Specimen Stability Information
Specimen Type
Temperature
Time
Whole blood
Refrigerated
28 days
Rejection Criteria
Rejection Criteria
Hemolysis
Gross reject
Lipemia
Gross reject
Performing Laboratory Information
Performing Laboratory Information
Performing Location
Day(s) Test Performed
Analytical Time
Methodology/Instrumentation
Mayo Clinic Laboratories
Monday through Friday
1 day
Hematofluorometry
Reference Lab
Mayo Clinic Laboratories
Test Information
Test Information
The porphyrins are intermediaries in the heme synthesis pathway. When iron is not available for heme synthesis (eg, iron deficiency), zinc protoporphyrin (ZPP) accumulates within red blood cells. Lead inhibits several enzymes in the heme synthesis pathway and causes increased levels of RBC ZPP. ZPP is a biological marker of lead toxicity and was previously used, in conjunction with blood lead assays, to screen for lead poisoning in children. However, because of poor sensitivity and specificity, ZPP is no longer recommended for lead screening in children. However, ZPP remains a useful tool for monitoring treatment of individuals with confirmed elevated lead levels.
Reference Range Information
Reference Range Information
Performing Location
Reference Range
Mayo Clinic Laboratories
<70 mcmol ZPP/mol heme
Interpretation
Interpretations
An elevated zinc protoporphyrin (ZPP) indicates impairment of the heme biosynthetic pathway.
Elevated ZPP levels in adults may indicate long-term (chronic) lead exposure or may be indicative of iron deficiency anemia or anemia of chronic disease.
Outreach CPTs
Outreach CPT Codes
CPT
Modifier
(if needed)
Quantity
Description
Comments
84202
Synonyms/Keywords
Synonyms, Keywords
Protoporphyrin, Zinc, Zinc Protoporphyrin
Ordering Applications
Ordering Applications
Ordering Application
Description
Centricity
Zinc Protoporphyrin, Blood
Cerner
None
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Requirements
Specimen Type
Preferred Container/Tube
Acceptable Container/Tube
Specimen Volume
Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Whole blood
Royal blue-top Monoject trace element blood collection tube, containing EDTA as an anticoagulant (RBTT)
1 mL
0.3 mL
Collection Processing
Collection Processing
See Mayo's
Lead/Heavy Metals Reporting Form.
Specimen Stability Information
Specimen Stability Information
Specimen Type
Temperature
Time
Whole blood
Refrigerated
28 days
Rejection Criteria
Rejection Criteria
Hemolysis
Gross reject
Lipemia
Gross reject
Useful For
Useful For
Evaluating iron deficiency
Monitoring treatment and environmental intervention of chronic lead poisoning
Reference Range Information
Reference Range Information
Performing Location
Reference Range
Mayo Clinic Laboratories
<70 mcmol ZPP/mol heme
Interpretation
Interpretations
An elevated zinc protoporphyrin (ZPP) indicates impairment of the heme biosynthetic pathway.
Elevated ZPP levels in adults may indicate long-term (chronic) lead exposure or may be indicative of iron deficiency anemia or anemia of chronic disease.
For more information visit:
http://labtestsonline.org
Performing Laboratory Information
Performing Laboratory Information
Performing Location
Day(s) Test Performed
Analytical Time
Methodology/Instrumentation
Mayo Clinic Laboratories
Monday through Friday
1 day
Hematofluorometry
Reference Lab
Mayo Clinic Laboratories
For billing questions, see Contacts
Outreach CPTs
Outreach CPT Codes
CPT
Modifier
(if needed)
Quantity
Description
Comments
84202
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For most current information refer to the Marshfield Laboratory online reference manual.