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# A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Strep pneumo IgG Ab Panel (PN23)
Test Code: PREPNSO
Synonyms/Keywords
Pneumococcal Antibody (IgG) 23 Serotype Panel
Strep Antibodies
Strep Pneumo Antibodies
Strep Pneumoniae Antibody
Strep Vaccine
Streptococcus Pneumoniae
Vaccine
Test Components
Active immunization of adults and children >2 years is performed with nonconjugated polysaccharide vaccines (Pneumovax and Pnu-Immune 23) that contain a total of 23 serotypes, namely 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F.(3) These 23 serotypes were included because, as a group, they account for approximately 90% of invasive pneumococcal infections.
Useful For
Assessing the IgG antibody response to active immunization with nonconjugated, 23-valent vaccines
 
Assessing the IgG antibody response to active immunization with conjugated, 13-valent vaccines
 
Determining the ability of an individual to produce an antibody response to polysaccharide antigen(s), as part of an evaluation for humoral or combined immunodeficiencies
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Serum ​Serum Separator Tube (SST) ​​Red Top Tube (RTT) ​0.5 mL ​0.4 mL
Specimen Stability Information
Specimen Type Temperature Time​​
​Serum ​Ambient, Refrigerated or frozen ​21 days
Rejection Criteria
​Gross Hemolysis, Gross Lipemia
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories ​Monday through Friday ​4 days ​Microsphere Photometry
Reference Lab
Reference Range Information
Performing Location Reference Range
Mayo Medical Laboratories
Serotype
Normal Value
1 (1)
 > or =2.3
2 (2)
 > or =1.0
3 (3)
 > or =1.8
4 (4)
 > or =0.6
5 (5)
 > or =10.7
8 (8)
 > or =2.9
9N (9)
 > or =9.2
12F (12)
 > or =0.6
14 (14)
 > or =7.0
17F (17)
 > or =7.8
19F (19)
 > or =15.0
20 (20)
 > or =1.3
22F (22)
 > or =7.2
23F (23)
 > or =8.0
6B (26)
 > or =4.7
10A (34)
 > or =2.9
11A (43)
 > or =2.4
7F (51)
 > or =3.2
15B (54)
 > or =3.3
18C (56)
 > or =3.3
19A (57)
 > or =17.1
9V (68)
 > or =2.6
33F (70)
 > or =1.7
Interpretation
As a general guideline, nonimmunocompromised adults develop IgG antibodies approximately 4 to 6 weeks following nonconjugated vaccination. A study conducted at the Mayo Clinic assessed IgG antibody concentrations prior to and following vaccination in a cohort of 100 healthy adults who met stringent exclusion criteria, including lack of previous pneumococcal vaccination or pneumonia associated with Streptococcus pneumoniae infection. Based on this data, reference ranges were established that most effectively discriminated between prevaccination and postvaccination antibody concentrations. Antibody concentrations greater than or equal to the reference value for at least 50% of serotypes in either a pre- or postvaccination specimen or a 2-fold or greater increase in antibody concentrations for at least 50% of serotypes when comparing the pre- to the postvaccination results would be consistent with a normal response to Streptococcus pneumoniae vaccination.
 
Serotype-specific antibodies may persist for up to 10 years following immunization or infection.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​86317 ​23 ​Immunoassay for infectious agent ab, quant, not otherwise specified
Synonyms/Keywords
Pneumococcal Antibody (IgG) 23 Serotype Panel
Strep Antibodies
Strep Pneumo Antibodies
Strep Pneumoniae Antibody
Strep Vaccine
Streptococcus Pneumoniae
Vaccine
Test Components
Active immunization of adults and children >2 years is performed with nonconjugated polysaccharide vaccines (Pneumovax and Pnu-Immune 23) that contain a total of 23 serotypes, namely 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F.(3) These 23 serotypes were included because, as a group, they account for approximately 90% of invasive pneumococcal infections.
Ordering Applications
Ordering Application Description
​Centricity ​Pneumococcal Ab (12 serotypes)
​Cerner ​None
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Serum ​Serum Separator Tube (SST) ​​Red Top Tube (RTT) ​0.5 mL ​0.4 mL
Specimen Stability Information
Specimen Type Temperature Time​​
​Serum ​Ambient, Refrigerated or frozen ​21 days
Rejection Criteria
​Gross Hemolysis, Gross Lipemia
Useful For
Assessing the IgG antibody response to active immunization with nonconjugated, 23-valent vaccines
 
Assessing the IgG antibody response to active immunization with conjugated, 13-valent vaccines
 
Determining the ability of an individual to produce an antibody response to polysaccharide antigen(s), as part of an evaluation for humoral or combined immunodeficiencies
Reference Range Information
Performing Location Reference Range
Mayo Medical Laboratories
Serotype
Normal Value
1 (1)
 > or =2.3
2 (2)
 > or =1.0
3 (3)
 > or =1.8
4 (4)
 > or =0.6
5 (5)
 > or =10.7
8 (8)
 > or =2.9
9N (9)
 > or =9.2
12F (12)
 > or =0.6
14 (14)
 > or =7.0
17F (17)
 > or =7.8
19F (19)
 > or =15.0
20 (20)
 > or =1.3
22F (22)
 > or =7.2
23F (23)
 > or =8.0
6B (26)
 > or =4.7
10A (34)
 > or =2.9
11A (43)
 > or =2.4
7F (51)
 > or =3.2
15B (54)
 > or =3.3
18C (56)
 > or =3.3
19A (57)
 > or =17.1
9V (68)
 > or =2.6
33F (70)
 > or =1.7
Interpretation
As a general guideline, nonimmunocompromised adults develop IgG antibodies approximately 4 to 6 weeks following nonconjugated vaccination. A study conducted at the Mayo Clinic assessed IgG antibody concentrations prior to and following vaccination in a cohort of 100 healthy adults who met stringent exclusion criteria, including lack of previous pneumococcal vaccination or pneumonia associated with Streptococcus pneumoniae infection. Based on this data, reference ranges were established that most effectively discriminated between prevaccination and postvaccination antibody concentrations. Antibody concentrations greater than or equal to the reference value for at least 50% of serotypes in either a pre- or postvaccination specimen or a 2-fold or greater increase in antibody concentrations for at least 50% of serotypes when comparing the pre- to the postvaccination results would be consistent with a normal response to Streptococcus pneumoniae vaccination.
 
Serotype-specific antibodies may persist for up to 10 years following immunization or infection.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Mayo Medical Laboratories ​Monday through Friday ​4 days ​Microsphere Photometry
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​86317 ​23 ​Immunoassay for infectious agent ab, quant, not otherwise specified
For most current information refer to the Marshfield Laboratory online reference manual.