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22889 Mumps Virus Antibody, IgG and IgM, (MMPGM)

Mumps Virus Antibody, IgG and IgM, (MMPGM)
Test Code: MUMPSDO
Synonyms/Keywords
Mumps Serology, Mumps Antibody, Mumps Ab, Diagnostic IgG & IgM (MMPGM)
Useful For
Laboratory diagnosis of mumps virus infection.
 
Determination of postimmunization immune response of individuals to the mumps vaccine.
 
Documentation of previous infection with mumps virus in an individual with no previous record of immunization to mumps virus.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Serum​ Serum Separator Tube (SST) Red Top Tube (RTT) ​1.0 mL ​0.9 mL
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Refrigerated (preferred) ​14 days
​Frozen ​14 days
Rejection Criteria
Hemolysis Gross reject
​Lipemia ​    Gross reject
​Other Heat-inactivated specimen​
Interference

Serum specimens obtained during the acute phase of infection or soon after vaccination may be negative for IgM- or IgG-class antibodies by serological tests.

All positive IgM results must be interpreted cautiously as some false-positive results or heterotypical responses of the IgM have been seen in the serum of pregnant women or in patients with an acute infection caused by cytomegalovirus, herpes simplex virus, measles, rubella, or parvovirus. 

Testing for IgM-class antibodies to mumps virus should be limited to patients with a clinically compatible disease.

Mumps virus shares antigenic relationships with other viruses of the paramyxovirus group; therefore serologic cross-reactions are possible, but uncommon with this test procedure.

IgG-class antibodies to mumps virus may be present in serum specimens from individuals who have received blood products within the past several months, but have not been immunized or experienced past infection with this virus.

Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
​Mayo Clinic Laboratories
Monday through Saturday
1 to 3 days
MMPM: Enzyme Immunoassay (EIA)
MPPG: Multiplex Flow Immunoassay
Reference Lab
Reference Range Information

IgM:

Negative

Index value 0.00-0.79 =negative

Reference values apply to all ages.

IgG:

Vaccinated: Positive (> or =1.1 AI)

Unvaccinated: Negative (< or =0.8 AI)

Reference values apply to all ages.

Interpretation

A positive IgG result coupled with a positive IgM result suggests recent infection with mumps virus. This result should not be used alone to diagnose mumps infection and should be interpreted in the context of clinical presentation.

A positive IgG result coupled with a negative IgM result indicates previous vaccination to or infection with mumps virus. These individuals are considered to have protective immunity to reinfection.

A negative IgG result coupled with a negative IgM result indicates the absence of prior exposure to mumps virus and nonimmunity. However, a negative result does not rule-out mumps infection or response to vaccination. The specimen may have been collected before the appearance of detectable antibodies. Negative results in suspected early mumps infection or within a week following vaccination should be followed by testing a new serum specimen in 2 to 3 weeks.

Equivocal results should be followed up with testing of a new serum specimen within 10 to 14 days.

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
86735​ ​Mumps, IgG
​86735 ​Mumps, IgM
Synonyms/Keywords
Mumps Serology, Mumps Antibody, Mumps Ab, Diagnostic IgG & IgM (MMPGM)
Ordering Applications
Ordering Application Description
​Cerner ​Mumps Ab, Diagnostic IgG & IgM (MMPGM)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Serum​ Serum Separator Tube (SST) Red Top Tube (RTT) ​1.0 mL ​0.9 mL
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ ​Refrigerated (preferred) ​14 days
​Frozen ​14 days
Rejection Criteria
Hemolysis Gross reject
​Lipemia ​    Gross reject
​Other Heat-inactivated specimen​
Interference

Serum specimens obtained during the acute phase of infection or soon after vaccination may be negative for IgM- or IgG-class antibodies by serological tests.

All positive IgM results must be interpreted cautiously as some false-positive results or heterotypical responses of the IgM have been seen in the serum of pregnant women or in patients with an acute infection caused by cytomegalovirus, herpes simplex virus, measles, rubella, or parvovirus. 

Testing for IgM-class antibodies to mumps virus should be limited to patients with a clinically compatible disease.

Mumps virus shares antigenic relationships with other viruses of the paramyxovirus group; therefore serologic cross-reactions are possible, but uncommon with this test procedure.

IgG-class antibodies to mumps virus may be present in serum specimens from individuals who have received blood products within the past several months, but have not been immunized or experienced past infection with this virus.

Useful For
Laboratory diagnosis of mumps virus infection.
 
Determination of postimmunization immune response of individuals to the mumps vaccine.
 
Documentation of previous infection with mumps virus in an individual with no previous record of immunization to mumps virus.
Reference Range Information

IgM:

Negative

Index value 0.00-0.79 =negative

Reference values apply to all ages.

IgG:

Vaccinated: Positive (> or =1.1 AI)

Unvaccinated: Negative (< or =0.8 AI)

Reference values apply to all ages.

Interpretation

A positive IgG result coupled with a positive IgM result suggests recent infection with mumps virus. This result should not be used alone to diagnose mumps infection and should be interpreted in the context of clinical presentation.

A positive IgG result coupled with a negative IgM result indicates previous vaccination to or infection with mumps virus. These individuals are considered to have protective immunity to reinfection.

A negative IgG result coupled with a negative IgM result indicates the absence of prior exposure to mumps virus and nonimmunity. However, a negative result does not rule-out mumps infection or response to vaccination. The specimen may have been collected before the appearance of detectable antibodies. Negative results in suspected early mumps infection or within a week following vaccination should be followed by testing a new serum specimen in 2 to 3 weeks.

Equivocal results should be followed up with testing of a new serum specimen within 10 to 14 days.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
​Mayo Clinic Laboratories
Monday through Saturday
1 to 3 days
MMPM: Enzyme Immunoassay (EIA)
MPPG: Multiplex Flow Immunoassay
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
86735​ ​Mumps, IgG
​86735 ​Mumps, IgM
For most current information refer to the Marshfield Laboratory online reference manual.