Skip Ribbon Commands
Skip to main content
Sign In

22484 Cryofibrinogen

Cryofibrinogen
Test Code: CRYOFIB
Synonyms/Keywords
Cryofibrinogen in blood, Cryofib​
Useful For
This test is useful for determining cryofibrinogenemia.  Cryofibrinogen is a cold insoluble form of fibrinogen precipitating out of plasma at refrigerator temperatures.​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Plasma​
Citrated Blue
Top Tubes
(BTT)​
10 mL plasma​ 6 mL plasma​
Collection Processing Instructions
Draw 8 - 2.7 mL Citrated Blue Top Tubes (BTT).  Keep blood at 37°C (98.6° F) for at least 30 minutes, centrifuge for 5 minutes, and remove plasma immediately.   Refrigerate and indicate "plasma" on tube.
 
For Marshfield only:
1. Obtain a heated thermos container from Special Processing incubator.
2. Place tubes in thermos and cover immediately after drawing.
3. Hand carry specimen to Clinical Manual and give to personnel. After hours, place specimen in 37 deg. C waterbath.
4. Return empty thermos to 37 deg. C incubator for future use. The specimen must remain in the waterbath until it is processed by Special Chemistry personnel.​
Specimen Stability Information
Specimen Type Temperature Time
Plasma​ Refrigerated (once sample is centrifuged, and plasma is taken off)​ 7 days​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​

4 days

Results may be delayed if specimen requires immunofixation​

Cold precipitation, and if positive, Immunofixation

Test Information
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
 
After plasma is removed from cells, it is incubated at 2-8°C for 72 hours.  It is then centrifuged at 2-8°C and examined for the presence of precipitate.  Semi-quantitation is performed when precipitate is present.  Immunofixation is performed on the precipitate if it is > or = 0.4 % of the total volume.​
 
If immunofixation is required, it will be charged separately.
Reference Range Information
Performing Location Reference Range
Marshfield​

Negative

If Positive-interpretation, typing and quantitation are provided.​

Interpretation
Cryofibrinogen can be associated with multiple myeloma, gastric, ovarian and prostatic carcinoma, fibrosarcoma, acute rheumatic fever, ulcerative colitis, and in some diseases where cryoglobulins are present.  An essential form has been described that is not associated wiht a disease state, but may be seen in conjunction with purpura and gangreene of the extremities that is secondary to peripheral vascular occlusion.​
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
82585​
​86334 ​Immunofixation (if needed)
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Synonyms/Keywords
Cryofibrinogen in blood, Cryofib​
Ordering Applications
Ordering Application Description
​Centricity ​Cryofibrinogen
​Cerner ​Cryofibrinogen
​COM ​Cryofibrinogen
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Plasma​
Citrated Blue
Top Tubes
(BTT)​
10 mL plasma​ 6 mL plasma​
Collection Processing
Draw 8 - 2.7 mL Citrated Blue Top Tubes (BTT).  Keep blood at 37°C (98.6° F) for at least 30 minutes, centrifuge for 5 minutes, and remove plasma immediately.   Refrigerate and indicate "plasma" on tube.
 
For Marshfield only:
1. Obtain a heated thermos container from Special Processing incubator.
2. Place tubes in thermos and cover immediately after drawing.
3. Hand carry specimen to Clinical Manual and give to personnel. After hours, place specimen in 37 deg. C waterbath.
4. Return empty thermos to 37 deg. C incubator for future use. The specimen must remain in the waterbath until it is processed by Special Chemistry personnel.​
Specimen Stability Information
Specimen Type Temperature Time
Plasma​ Refrigerated (once sample is centrifuged, and plasma is taken off)​ 7 days​
Useful For
This test is useful for determining cryofibrinogenemia.  Cryofibrinogen is a cold insoluble form of fibrinogen precipitating out of plasma at refrigerator temperatures.​
Reference Range Information
Performing Location Reference Range
Marshfield​

Negative

If Positive-interpretation, typing and quantitation are provided.​

Interpretation
Cryofibrinogen can be associated with multiple myeloma, gastric, ovarian and prostatic carcinoma, fibrosarcoma, acute rheumatic fever, ulcerative colitis, and in some diseases where cryoglobulins are present.  An essential form has been described that is not associated wiht a disease state, but may be seen in conjunction with purpura and gangreene of the extremities that is secondary to peripheral vascular occlusion.​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​

4 days

Results may be delayed if specimen requires immunofixation​

Cold precipitation, and if positive, Immunofixation

For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
82585​
​86334 ​Immunofixation (if needed)
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
For most current information refer to the Marshfield Laboratory online reference manual.