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22420 Chlamydia Serology, Serum (SCLAM)

Chlamydia Serology, Serum (SCLAM)
Test Code: CHLSO
Synonyms/Keywords
Bedsonia, Chlamydia trachomatis Antibodies, Chlamydophila pneumonia, Chlamydophila psittaci, TWAR, LGV (Lymphogranuloma Venereum), Ornithosis, Psittacosis, Chlamydia Antibodies Differentiation Panel, Chlamydia Antibodies, IgG and IgM, Chlamydia Differentiation Antibody Panel, Chlamydia pneumoniae (TWAR), Chlamydia pneumoniae, IgG and IgM, Chlamydia psittaci, IgG and IgM, Chlamydia Species Differentiation Antibody Panel, Chlamydia trachomatis Antibody, Chlamydia trachomatis, IgG and IgM, Chlamydia TWAR, Chlamydophila, Chlamydophila pneumonia, Chlamydophila psattaci, Lymphogranuloma Venereum (LGV) Antibodies, Psittacosis Antibodies, TWAR (Chlamydia pneumoniae)
Test Components

​Includes Chlamydophila pneumoniae, Chlamydophila psittaci, and Chlamydia trachomatis. 

Useful For
Aiding in the clinical diagnosis of chlamydia infections
 
This test is NOT intended for medical-legal use
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Serum​ Serum Separator Tube (SST) ​Red Top Tube (RTT) ​0.2 mL ​0.15 mL
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ Refrigerated (preferred)​ ​30 days
​Frozen ​30 days
Rejection Criteria
Hemolysis
 Gross reject
​Lipemia
Gross reject
Interference

​Antichlamydial IgG can persist for years. All results from chlamydial serologies must correlate with clinical history and other data available to the physician.

Specimens collected too early during primary infection may not contain detectable antibodies. If chlamydial infection is suspected, a second specimen should be collected 10 to 21 days later and tested in parallel with the original specimen.

During a primary Chlamydia infection, the early antibody response may be cross-reactive with multiple Chlamydia species.

The Chlamydia microimmunofluorescent antibody assay utilizes serotypes D-K of Chlamydia trachomatis. Sera from suspected cases of lymphogranuloma venereum (LGV) should be tested by a Lymphogranuloma Venereum Differentiation Antibody Panel. LGV testing is not performed by Mayo Clinic Laboratories; call 800-533-1710 for further assistance.

Due to the limited sensitivity and specificity of Chlamydia serologic tests, patients with suspected C trachomatis infection should be tested by a molecular method (eg, CTRNA / Chlamydia trachomatis by Nucleic Acid Amplification [HOLOGIC], Varies) when clinical manifestations are present. 

Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
Mayo Clinic Laboratories​​
Monday through Friday
1 to 4 days
Micro-Immunofluorescent Antibody (MIF) Assay
Reference Lab
Reference Range Information
Reference Range
Chlamydophila pneumoniae
IgG: <1:64
IgM: <1:10
 
Chlamydophila psittaci
IgG: <1:64
IgM: <1:10
 
Chlamydia trachomatis
IgG: <1:64
IgM: <1:10
Interpretation

IgG:

Chlamydophila pneumoniae

> or =1:512

IgG endpoint titers of 1:512 or more are considered presumptive evidence of current infection.

<1:512 and > or =1:64

A single specimen endpoint titer of  from 1:64 to 1:512 should be considered evidence of infection at an undetermined time. A second specimen drawn 10 to 21 days after the original draw should be tested in parallel with the first. If the second specimen exhibits a titer 1:512 or more or a 4-fold increase over that of the initial specimen, current (acute) infection is indicated. Unchanging titers from 1:64 to 1:512 suggest past infection.

<1:64

IgG endpoint titers below 1:64 suggest that the patient does not have a current infection. These antibody levels may be found in patients with either no history of chlamydial infection or those with past infection whose antibody levels have dropped below detectable levels.

Chlamydophila pneumoniae antibody is detectable in 25% to 45% of adults tested.

Chlamydophila psittaci and Chlamydia trachomatis

> or =1:64

IgG endpoint titers of 1:64 or more are considered presumptive evidence of current infection.

<1:64

IgG endpoint titers below 1:64 suggest that the patient does not have a current infection. These antibody levels may be found in patients with either no history of chlamydial infection or those with past infection whose antibody levels have dropped below detectable levels.

IgM

Chlamydophila pneumoniae, Chlamydophila psittaci, and Chlamydia trachomatis

> or =1:10

IgM endpoint titers of 1:10 or more are considered presumptive evidence of infection.

<1:10

IgM endpoint titers below 1:10 suggest that the patient does not have a current infection. These antibody levels may be found in patients with either no history of chlamydial infection or those with past infection whose antibody levels have dropped below detectable levels. 

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​86631 ​3 ​Chlamydia IgG Ab
​86632 ​3 ​Chlamydia IgM Ab
Synonyms/Keywords
Bedsonia, Chlamydia trachomatis Antibodies, Chlamydophila pneumonia, Chlamydophila psittaci, TWAR, LGV (Lymphogranuloma Venereum), Ornithosis, Psittacosis, Chlamydia Antibodies Differentiation Panel, Chlamydia Antibodies, IgG and IgM, Chlamydia Differentiation Antibody Panel, Chlamydia pneumoniae (TWAR), Chlamydia pneumoniae, IgG and IgM, Chlamydia psittaci, IgG and IgM, Chlamydia Species Differentiation Antibody Panel, Chlamydia trachomatis Antibody, Chlamydia trachomatis, IgG and IgM, Chlamydia TWAR, Chlamydophila, Chlamydophila pneumonia, Chlamydophila psattaci, Lymphogranuloma Venereum (LGV) Antibodies, Psittacosis Antibodies, TWAR (Chlamydia pneumoniae)
Test Components

​Includes Chlamydophila pneumoniae, Chlamydophila psittaci, and Chlamydia trachomatis. 

Ordering Applications
Ordering Application Description
​Centricity ​Chlamydia Serology (SCLAM)
​Cerner ​Chlamydia Serology (SCLAM)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
Serum​ Serum Separator Tube (SST) ​Red Top Tube (RTT) ​0.2 mL ​0.15 mL
Specimen Stability Information
Specimen Type Temperature Time
​Serum ​ Refrigerated (preferred)​ ​30 days
​Frozen ​30 days
Rejection Criteria
Hemolysis
 Gross reject
​Lipemia
Gross reject
Interference

​Antichlamydial IgG can persist for years. All results from chlamydial serologies must correlate with clinical history and other data available to the physician.

Specimens collected too early during primary infection may not contain detectable antibodies. If chlamydial infection is suspected, a second specimen should be collected 10 to 21 days later and tested in parallel with the original specimen.

During a primary Chlamydia infection, the early antibody response may be cross-reactive with multiple Chlamydia species.

The Chlamydia microimmunofluorescent antibody assay utilizes serotypes D-K of Chlamydia trachomatis. Sera from suspected cases of lymphogranuloma venereum (LGV) should be tested by a Lymphogranuloma Venereum Differentiation Antibody Panel. LGV testing is not performed by Mayo Clinic Laboratories; call 800-533-1710 for further assistance.

Due to the limited sensitivity and specificity of Chlamydia serologic tests, patients with suspected C trachomatis infection should be tested by a molecular method (eg, CTRNA / Chlamydia trachomatis by Nucleic Acid Amplification [HOLOGIC], Varies) when clinical manifestations are present. 

Useful For
Aiding in the clinical diagnosis of chlamydia infections
 
This test is NOT intended for medical-legal use
Test Components

​Includes Chlamydophila pneumoniae, Chlamydophila psittaci, and Chlamydia trachomatis. 

Reference Range Information
Reference Range
Chlamydophila pneumoniae
IgG: <1:64
IgM: <1:10
 
Chlamydophila psittaci
IgG: <1:64
IgM: <1:10
 
Chlamydia trachomatis
IgG: <1:64
IgM: <1:10
Interpretation

IgG:

Chlamydophila pneumoniae

> or =1:512

IgG endpoint titers of 1:512 or more are considered presumptive evidence of current infection.

<1:512 and > or =1:64

A single specimen endpoint titer of  from 1:64 to 1:512 should be considered evidence of infection at an undetermined time. A second specimen drawn 10 to 21 days after the original draw should be tested in parallel with the first. If the second specimen exhibits a titer 1:512 or more or a 4-fold increase over that of the initial specimen, current (acute) infection is indicated. Unchanging titers from 1:64 to 1:512 suggest past infection.

<1:64

IgG endpoint titers below 1:64 suggest that the patient does not have a current infection. These antibody levels may be found in patients with either no history of chlamydial infection or those with past infection whose antibody levels have dropped below detectable levels.

Chlamydophila pneumoniae antibody is detectable in 25% to 45% of adults tested.

Chlamydophila psittaci and Chlamydia trachomatis

> or =1:64

IgG endpoint titers of 1:64 or more are considered presumptive evidence of current infection.

<1:64

IgG endpoint titers below 1:64 suggest that the patient does not have a current infection. These antibody levels may be found in patients with either no history of chlamydial infection or those with past infection whose antibody levels have dropped below detectable levels.

IgM

Chlamydophila pneumoniae, Chlamydophila psittaci, and Chlamydia trachomatis

> or =1:10

IgM endpoint titers of 1:10 or more are considered presumptive evidence of infection.

<1:10

IgM endpoint titers below 1:10 suggest that the patient does not have a current infection. These antibody levels may be found in patients with either no history of chlamydial infection or those with past infection whose antibody levels have dropped below detectable levels. 

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
Mayo Clinic Laboratories​​
Monday through Friday
1 to 4 days
Micro-Immunofluorescent Antibody (MIF) Assay
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​86631 ​3 ​Chlamydia IgG Ab
​86632 ​3 ​Chlamydia IgM Ab
For most current information refer to the Marshfield Laboratory online reference manual.