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22348 Beta-2 Microglobulin, Urine (B2MU)

Beta-2 Microglobulin, Urine (B2MU)
Test Code: B2MRUSO
Synonyms/Keywords
B2M, (Beta-2 Microglobulin) Urine; Beta 2 Microglobulin Test, Beta-2 Microglobulin, Urine
Useful For
​Evaluation of renal tubular damage
 
Monitoring exposure to cadmium and mercury
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Urine Plastic, 10-mL urine tube ​ ​Sterile Container 3 mL​ 1  mL​
Collection Processing Instructions

1. Patient should empty bladder.

2. Have patient drink at least 0.5 liters of water.

3. Within 1 hour, collect a random urine specimen.

4. Add 1 M sodium hydroxide (NaOH) as preservative to the collection. This preservative is intended to achieve a pH of between approximately 6 and 8.

Patient Preparation: For 12 hours before specimen collection, do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Specimen Stability Information
Specimen Type Temperature Time
Urine​ ​ Frozen (preferred)​ 14 days​
Refrigerated ​ 48 hours​
Rejection Criteria

​Specimen with pH <6

Interference

​Degradation of beta-2 microglobulin occurs at pH <6.0.

Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
Mayo Clinic Laboratories
Monday, Wednesday, Friday
1 to 3 days​
Automated Chemiluminescent Immunometric Assay
Reference Lab
Test Information
​Beta-2-microglobulin is a low-molecular-weight protein that forms the light chain component of class I histocompatibility (HLA [human leukocyte antigen]) antigens. Increased urine levels are seen in proximal tubular renal damage due to a variety of causes, including cadmium, mercury, lithium, or aminoglycoside toxicity pyelonephritis; and Balkan nephropathy, a chronic interstitial nephritis of unknown etiology.
Reference Range Information
< or = 300 mcg/L
Interpretation
​Increased excretion is consistent with renal tubular damage.
 
Beta-2-microglobulin excretion is increased 100 to 1,000 times normal levels in cadmium-exposed workers.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
82232​ Beta-2 microglobulin​
Synonyms/Keywords
B2M, (Beta-2 Microglobulin) Urine; Beta 2 Microglobulin Test, Beta-2 Microglobulin, Urine
Ordering Applications
Ordering Application Description
​Centricity ​Beta-2 Microglobulin (300243)
​Cerner ​Beta 2 Microglobulin Urine (300245)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Urine Plastic, 10-mL urine tube ​ ​Sterile Container 3 mL​ 1  mL​
Collection Processing

1. Patient should empty bladder.

2. Have patient drink at least 0.5 liters of water.

3. Within 1 hour, collect a random urine specimen.

4. Add 1 M sodium hydroxide (NaOH) as preservative to the collection. This preservative is intended to achieve a pH of between approximately 6 and 8.

Patient Preparation: For 12 hours before specimen collection, do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Specimen Stability Information
Specimen Type Temperature Time
Urine​ ​ Frozen (preferred)​ 14 days​
Refrigerated ​ 48 hours​
Rejection Criteria

​Specimen with pH <6

Interference

​Degradation of beta-2 microglobulin occurs at pH <6.0.

Useful For
​Evaluation of renal tubular damage
 
Monitoring exposure to cadmium and mercury
Reference Range Information
< or = 300 mcg/L
Interpretation
​Increased excretion is consistent with renal tubular damage.
 
Beta-2-microglobulin excretion is increased 100 to 1,000 times normal levels in cadmium-exposed workers.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
Mayo Clinic Laboratories
Monday, Wednesday, Friday
1 to 3 days​
Automated Chemiluminescent Immunometric Assay
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
82232​ Beta-2 microglobulin​
For most current information refer to the Marshfield Laboratory online reference manual.