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SM-RNP Antibodies
Test Code: SMRNP
Synonyms/Keywords
SMRNP, ENA, Extractable Nuclear Antibodies Sm & RNP​, Smith Antibody
Useful For
The SmRNP assay tests for antibody to Sm, SmRNP, and RNP. Sm or Smith antibody is considered a marker for SLE. It occurs in a minority of SLE patients, but is highly specific. Reactivity to the SmRNP epitope may be present when antibody is undetectable by individual assays for Sm or RNP.​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) or Serum Separator Tube (SST)​ 1.0 mL​ 0.5 mL​ 0.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerate​ 7 days​
Frozen > 7 days​
Rejection Criteria
Gross lipemia
Gross hemolysis​
Heat inactivated samples​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
Reference Range Information
Performing Location Reference Range
Marshfield ​
Negative <1.0
Analytical measuring range is 0.2 -8.0 AI (Antibody Index)​
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
86235​
Synonyms/Keywords
SMRNP, ENA, Extractable Nuclear Antibodies Sm & RNP​, Smith Antibody
Ordering Applications
Ordering Application Description
​Centricity ​Sm-RNP Antibodies
​Cerner ​Sm-RNP Antibodies
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Serum​ Red Top Tube (RTT) or Serum Separator Tube (SST)​ 1.0 mL​ 0.5 mL​ 0.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Serum​ Refrigerate​ 7 days​
Frozen > 7 days​
Rejection Criteria
Gross lipemia
Gross hemolysis​
Heat inactivated samples​
Useful For
The SmRNP assay tests for antibody to Sm, SmRNP, and RNP. Sm or Smith antibody is considered a marker for SLE. It occurs in a minority of SLE patients, but is highly specific. Reactivity to the SmRNP epitope may be present when antibody is undetectable by individual assays for Sm or RNP.​
Reference Range Information
Performing Location Reference Range
Marshfield ​
Negative <1.0
Analytical measuring range is 0.2 -8.0 AI (Antibody Index)​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday through Friday​ 1 day​ Multiplex Flow Immunoassay/Bio-Rad BioPlex 2200​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
86235​
For most current information refer to the Marshfield Laboratory online reference manual.