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22321 Gastric Parietal Antibody, IgG

Gastric Parietal Antibody, IgG
Test Code: PARIET
Synonyms/Keywords
Parietal Cell Antibody- Serum, Gastric Parietal Cell​, Pernicious Anemia, Gastric Parietal Antibodies, IgG
Useful For
Gastric parietal antibodies (GPA) occur in the serum of a majority of patients with pernicious anemia (PA). A positive GPA along with other clinical and laboratory data, helps to distinguish autoimmune PA from other megaloblastic anemias. Although detected in less than 2% of the normal population under 20 years of age, the incidence of GPA increases in women over the age of 40 and may be present in up to 16% of the normal population over 60 years of age.​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​Serum​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​1.0 mL​0.75 mL​0.5 mL​
Collection Processing Instructions

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ ​ Ambient​ 8 hours
Refrigerate 2-8 deg Celsius 2 days​
Frozen at -20 deg Celsius ​> 2 days
Rejection Criteria
Gross hemolysis
Gross lipemia ​
​Heat treated samples
​Microbial contamination
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday - Friday
 Same day/1 day​ Indirect Immunofluorescence (IFA)​
Test Information
Positives will be titered.​
Reference Range Information
Performing Location Reference Range
Marshfield​ Negative (<1:10)  ​
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86255 ​ ​ ​ ​ ​
Synonyms/Keywords
Parietal Cell Antibody- Serum, Gastric Parietal Cell​, Pernicious Anemia, Gastric Parietal Antibodies, IgG
Ordering Applications
Ordering Application Description
​Cerner ​Gastric Parietal Antibody, IgG
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)		 Pediatric Minimum Volume
(no repeat)
No​Serum​Red Top Tube (RTT) ​Serum Separator Tube (SST) ​1.0 mL​0.75 mL​0.5 mL​
Collection Processing

​Separate serum from cells within 2 hours of collection.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ ​ Ambient​ 8 hours
Refrigerate 2-8 deg Celsius 2 days​
Frozen at -20 deg Celsius ​> 2 days
Rejection Criteria
Gross hemolysis
Gross lipemia ​
​Heat treated samples
​Microbial contamination
Useful For
Gastric parietal antibodies (GPA) occur in the serum of a majority of patients with pernicious anemia (PA). A positive GPA along with other clinical and laboratory data, helps to distinguish autoimmune PA from other megaloblastic anemias. Although detected in less than 2% of the normal population under 20 years of age, the incidence of GPA increases in women over the age of 40 and may be present in up to 16% of the normal population over 60 years of age.​
Reference Range Information
Performing Location Reference Range
Marshfield​ Negative (<1:10)  ​
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday - Friday
 Same day/1 day​ Indirect Immunofluorescence (IFA)​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)		 Quantity Description Comments
86255 ​ ​ ​ ​ ​
For most current information refer to the Marshfield Laboratory online reference manual.