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22295 Angiotensin Converting Enzyme, Serum (ACE)

Angiotensin Converting Enzyme, Serum (ACE)
Test Code: ACESO
Synonyms/Keywords
​ACE (Angiotensin Converting Enzyme) Angiotensin-1-Converting Enzyme Kinase II Peptidylpeptide Hydrolase SACE (Serum Angiotensin Convert
Angiotensin-1-Converting Enzyme
Kinase II
Peptidylpeptide Hydrolase
SACE (Serum Angiotensin Converting Enzyme)
Sarcoidosis
Serum Angiotensin Converting Enzyme
ACE (Angiotensin Converting Enzyme)
Useful For
Evaluation of patients with suspected sarcoidosis
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Serum​ Serum Separator Tube (SST)

Red Top Tube (RTT)

0.5 mL​ 0.5 mL​
Collection Processing Instructions

​The use of angiotensin converting enzyme (ACE)-inhibiting antihypertensive drugs will cause decreased ACE values. Patients taking ACE inhibitors, such as captopril and enalapril, will have extremely low or unmeasurable ACE activity. Indicate on the request form if the patient is on ACE inhibitors.

Specimen Stability Information
Specimen Type Temperature Time
Serum ​ ​
Refrigerated​ (preferred) 7 days​
Frozen ​180 days
​Ambient ​24 hours
Rejection Criteria
Gross Hemolysis ​
Gross Lipemia​
​Gross Icterus

 

Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/ Instrumentation
Mayo Clinic Laboratories Monday through Sunday 1 to 3 days Spectrophotometry
Reference Lab
Test Information

Angiotensin converting enzyme (ACE) is integral to the renin-angiotensin system (RAS), which maintains blood pressure by regulation of fluid volume and vascular tension. Its peptidase action on the decapeptide angiotensinogen I results in the hydrolysis of a terminal histidyl leucine dipeptide and the formation of the octapeptide angiotensin II, a potent vasoconstrictor that increases blood pressure.

ACE activity is increased in sarcoidosis, a systemic granulomatous disease that commonly affects the lungs. In sarcoidosis, ACE is thought to be produced by epithelioid cells and macrophages of the granuloma.

ACE activity reflects the severity of sarcoidosis: 68% positivity in those with stage I sarcoidosis, 86% in stage II sarcoidosis, and 91% in stage III sarcoidosis.

Other conditions such as Gaucher disease, leprosy, untreated hyperthyroidism, psoriasis, premature infants with respiratory distress syndrome, adults with amyloidosis, and histoplasmosis have been associated with increased serum ACE activity.

Reference Range Information

> or =18 years: 16-85 U/L

0-17 years: ACE activity may be 20-50% higher in healthy children compared to healthy adults (16-85 U/L).

Interpretation

​An elevation in the level of serum angiotensin converting enzyme (ACE), along with radiographic evidence of infiltrates or adenopathy and organ biopsies showing noncaseating epithelial granulomas is suggestive of a diagnosis of sarcoidosis.

Normal, healthy children and infants are known to have ACE activity levels greater than the adult reference interval.

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
82164​
Classification
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
Synonyms/Keywords
​ACE (Angiotensin Converting Enzyme) Angiotensin-1-Converting Enzyme Kinase II Peptidylpeptide Hydrolase SACE (Serum Angiotensin Convert
Angiotensin-1-Converting Enzyme
Kinase II
Peptidylpeptide Hydrolase
SACE (Serum Angiotensin Converting Enzyme)
Sarcoidosis
Serum Angiotensin Converting Enzyme
ACE (Angiotensin Converting Enzyme)
Ordering Applications
Ordering Application Description
​Centricity

​ACE (Angiotensin Converting Enzyme)

and

Angiotensin Conv Ez. (ACE)

​Cerner ​Angiotensin Converting Enzyme
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Serum​ Serum Separator Tube (SST)

Red Top Tube (RTT)

0.5 mL​ 0.5 mL​
Collection Processing

​The use of angiotensin converting enzyme (ACE)-inhibiting antihypertensive drugs will cause decreased ACE values. Patients taking ACE inhibitors, such as captopril and enalapril, will have extremely low or unmeasurable ACE activity. Indicate on the request form if the patient is on ACE inhibitors.

Specimen Stability Information
Specimen Type Temperature Time
Serum ​ ​
Refrigerated​ (preferred) 7 days​
Frozen ​180 days
​Ambient ​24 hours
Rejection Criteria
Gross Hemolysis ​
Gross Lipemia​
​Gross Icterus

 

Useful For
Evaluation of patients with suspected sarcoidosis
Reference Range Information

> or =18 years: 16-85 U/L

0-17 years: ACE activity may be 20-50% higher in healthy children compared to healthy adults (16-85 U/L).

Interpretation

​An elevation in the level of serum angiotensin converting enzyme (ACE), along with radiographic evidence of infiltrates or adenopathy and organ biopsies showing noncaseating epithelial granulomas is suggestive of a diagnosis of sarcoidosis.

Normal, healthy children and infants are known to have ACE activity levels greater than the adult reference interval.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/ Instrumentation
Mayo Clinic Laboratories Monday through Sunday 1 to 3 days Spectrophotometry
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
82164​
Classification
This test was developed and its performance characteristics determined by Marshfield Labs. This laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA) to perform high complexity testing.
For most current information refer to the Marshfield Laboratory online reference manual.