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22291 Cocaine Metabolite, Urine

Cocaine Metabolite, Urine
Test Code: COC
Synonyms/Keywords
​Benzoylecgonine
Useful For
​Detecting abuse of cocaine
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 5 mL​ 3 mL​ 1.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Ambient​ 72 hours​
Refrigerate (Preferred)​ 30 days​
Frozen​ 30 days​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Monday through Friday​
If no confirmatory work is required: 1 day​
 
If confirmatory work is required: 4 days
Beckman Coulter AU680 Clinical Chemistry System with Emit Immunoassay and Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring (if needed for confirmation)​
Test Information
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
 

Cocaine is prepared from the leaves of the tropical bush Erythroxylon coca.  After use (snorting, smoking, or intravenous injection) cocaine is metabolized to benzoylecgonine (BZE) and ecgonine methyl ester (EME).  The BZE metabolite is analyzed since it is the metabolite that is detectable in urine for a longer period of time.

This test is a screen for cocaine by immunoassay; if the screen is positive, this test automatically includes LC-MS/MS confirmation for BZE. Quantitation and confirmation are charged separately if needed.  It is intended for use only in patients where an initial drug screening test has not already been performed (i.e. point-of-care drug screening cup, dipstick, etc.).​

Reference Range Information
Performing Location Reference Range
Marshfield​ ALL: Negative.  Positives are reported with a quantitative LC-MS/MS result.​
Interpretation

Current Cutoff Levels for Toxicology

The cocaine metabolite benzoylecgonine can be detected up to 3-5 days after last use.​

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
80307​ 1​ Single Drug Class​
80353 1​ Cocaine Metabolite Confirm by LC/MS/MS ​If needed
​G0480 ​1 ​Cocaine Metabolite Confirm by LC/MS/MS ​For Medicare/Medicaid, If needed
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
Synonyms/Keywords
​Benzoylecgonine
Ordering Applications
Ordering Application Description
​COM ​Cocaine, Urine
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
No​ Urine​ Sage urine collection container​ Sterile plastic container with no preservatives​ 5 mL​ 3 mL​ 1.5 mL​
Specimen Stability Information
Specimen Type Temperature Time
Urine​ Ambient​ 72 hours​
Refrigerate (Preferred)​ 30 days​
Frozen​ 30 days​
Useful For
​Detecting abuse of cocaine
Reference Range Information
Performing Location Reference Range
Marshfield​ ALL: Negative.  Positives are reported with a quantitative LC-MS/MS result.​
Interpretation

Current Cutoff Levels for Toxicology

The cocaine metabolite benzoylecgonine can be detected up to 3-5 days after last use.​

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
​Marshfield Monday through Friday​
If no confirmatory work is required: 1 day​
 
If confirmatory work is required: 4 days
Beckman Coulter AU680 Clinical Chemistry System with Emit Immunoassay and Liquid Chromatography/Tandem Mass Spectrometry (LCMS/MS) using Multiple Reaction Monitoring (if needed for confirmation)​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
80307​ 1​ Single Drug Class​
80353 1​ Cocaine Metabolite Confirm by LC/MS/MS ​If needed
​G0480 ​1 ​Cocaine Metabolite Confirm by LC/MS/MS ​For Medicare/Medicaid, If needed
Classification
This test was developed and its performance characteristics determined by Marshfield Labs.  It has not been cleared or approved by the US Food and Drug Administration.  This test is used for clinical purposes.  It should not be regarded as investigational or for research.
For most current information refer to the Marshfield Laboratory online reference manual.