Cocaine is prepared from the leaves of the tropical bush Erythroxylon coca. After use (snorting, smoking, or intravenous injection) cocaine is metabolized to benzoylecgonine (BZE) and ecgonine methyl ester (EME). The BZE metabolite is analyzed since it is the metabolite that is detectable in urine for a longer period of time.
This test is a screen for cocaine by immunoassay; if the screen is positive, this test automatically includes LC-MS/MS confirmation for BZE. Quantitation and confirmation are charged separately if needed. It is intended for use only in patients where an initial drug screening test has not already been performed (i.e. point-of-care drug screening cup, dipstick, etc.).
Current Cutoff Levels for Toxicology
The cocaine metabolite benzoylecgonine can be detected up to 3-5 days after last use.