Assessing patient compliance
Monitoring for appropriate therapeutic level
Assessing clonazepam toxicity
1. Draw blood immediately before next scheduled dose (minimum 12 hours after last dose).
2. Within 2 hours of collection, the specimen must be centrifuged and the serum aliquoted into a plastic vial.
Specimens that are obtained from gel tubes must be removed from the gel within 2 hours.
The therapeutic range varies depending on the indication.
Some individuals may respond well outside of these ranges or may display toxicity within the therapeutic range, and thus, interpretation should include clinical evaluation.
The possibility of toxicity is increased when levels exceed 100 ng/mL.