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22284 Clonazepam and 7-Aminoclonazepan, Serum (CZPS)

Clonazepam and 7-Aminoclonazepan, Serum (CZPS)
Test Code: CLONSO
Synonyms/Keywords
Klonopin (Clonazepam), Rivotril (Clonazepam), Clonazepam, 7-Aminoclonazepam
Useful For

Assessing patient compliance

Monitoring for appropriate therapeutic level

Assessing clonazepam toxicity

Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Serum Red Red Top Tube (RTT)​ 1.2 mL​ 0.6 mL​
Collection Processing Instructions

1. Draw blood immediately before next scheduled dose (minimum 12 hours after last dose).

2. Within 2 hours of collection, the specimen must be centrifuged and the serum aliquoted into a plastic vial.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ ​ Refrigerated (preferred)​ 14 days​
Ambient ​ 72 hours
Frozen ​ 28 days​
Rejection Criteria
Gross Icterus
Interference

​Specimens that are obtained from gel tubes must be removed from the gel within 2 hours.

Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
Mayo Clinic Laboratories
Tuesday​
2 to 9 days​
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)​
Reference Lab
Test Information
​This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements.  This test has not been cleared or approved by the U.S. Food and Drug Administration.
Reference Range Information
CLONAZEPAM
Anticonvulsant: 20-70 ng/mL
Anxiolytic: 4-80 ng/mL
Some individuals may show therapeutic response outside of these ranges, or may display toxicity within the therapeutic range, thus interpretation should include clinical evaluation. 
Note: Therapeutic ranges are for specimens drawn at trough (i.e. immediately before next scheduled dose).  Levels may be elevated in non-trough specimens.
Interpretation

​The therapeutic range varies depending on the indication.

Some individuals may respond well outside of these ranges or may display toxicity within the therapeutic range, and thus, interpretation should include clinical evaluation.

The possibility of toxicity is increased when levels exceed 100 ng/mL.

Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​80346
​G0480​(if appropriate)
Synonyms/Keywords
Klonopin (Clonazepam), Rivotril (Clonazepam), Clonazepam, 7-Aminoclonazepam
Ordering Applications
Ordering Application Description
​Centricity ​Clonazepam SO (8385)
​Cerner ​Clonazepam Level (500108)
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
(allows for 1 repeat)
Pediatric Minimum Volume
(no repeat)
​Serum Red Red Top Tube (RTT)​ 1.2 mL​ 0.6 mL​
Collection Processing

1. Draw blood immediately before next scheduled dose (minimum 12 hours after last dose).

2. Within 2 hours of collection, the specimen must be centrifuged and the serum aliquoted into a plastic vial.

Specimen Stability Information
Specimen Type Temperature Time
Serum​ ​ ​ Refrigerated (preferred)​ 14 days​
Ambient ​ 72 hours
Frozen ​ 28 days​
Rejection Criteria
Gross Icterus
Interference

​Specimens that are obtained from gel tubes must be removed from the gel within 2 hours.

Useful For

Assessing patient compliance

Monitoring for appropriate therapeutic level

Assessing clonazepam toxicity

Reference Range Information
CLONAZEPAM
Anticonvulsant: 20-70 ng/mL
Anxiolytic: 4-80 ng/mL
Some individuals may show therapeutic response outside of these ranges, or may display toxicity within the therapeutic range, thus interpretation should include clinical evaluation. 
Note: Therapeutic ranges are for specimens drawn at trough (i.e. immediately before next scheduled dose).  Levels may be elevated in non-trough specimens.
Interpretation

​The therapeutic range varies depending on the indication.

Some individuals may respond well outside of these ranges or may display toxicity within the therapeutic range, and thus, interpretation should include clinical evaluation.

The possibility of toxicity is increased when levels exceed 100 ng/mL.

For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Report Available Methodology/Instrumentation
Mayo Clinic Laboratories
Tuesday​
2 to 9 days​
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)​
Reference Lab
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
​80346
​G0480​(if appropriate)
For most current information refer to the Marshfield Laboratory online reference manual.