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22273 Chromosome Analysis, Bone Marrow

Chromosome Analysis, Bone Marrow
Test Code: CHRC-BM
Synonyms/Keywords
Karyotyping, Karyotype, Bone Marrow, Chromosome Culture, Bone Core Biopsy​
Useful For
Identifying chromosome anomalies in patients with possible hematologic neoplasms.  Information gained from this study may aid in determining diagnosis and prognosis as well as monitoring the patient's response to therapy.  ​
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
Pediatric Minimum Volume
No​ ​Bone Marrow Sodium-heparin Green Top Tube(GTT) ​ 3.0 mL  ​ 1.0 mL​ 1.0 mL​
Collection Processing Instructions
Invert the tube several times to assure that no clotting takes place.
 
If the patient has 10% or more circulating blasts, also send a peripheral blood specimen (green top tube -sodium heparin) to Cytogenetics. Notify Cytogenetics (800-222-5835, ext. 16388) when specimen is collected.
Include results of most recent hemogram (CBC and differential), pertinent clinical information and appropriate ICD-10 code(s).
 
Bone core biopsy is acceptable, collect in sterile media such as RPMI or Hanks.​
 
No contingent/ hold orders will be accepted Fridays or Saturdays due to loss of specimen integrity.
Contingent/ hold orders must be resolved by the client by 1500 Friday.
If notification is not received, chromosome analysis will be performed and charged. Contact the Cytogenetics Department at 715-221-6388.
Specimen Stability Information
Specimen Type Temperature Time
Bone Marrow​ Room Temperature  Overnight​
Refrigerate ​ If delay is longer than 24 hours​
Rejection Criteria
Frozen
Interference
If collected in tubes other than sodium heparin,(i.e. EDTA, lithium heparin)the growth and quality of the culture can be affected.​
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday - Saturday​ 2 weeks​ Manual​
Test Information
All patient specimens are prioritized by clinical indication.  Inquiries may be called to Cytogenetics (800-222-5835, ext. 16388).​
Reference Range Information
Performing Location Reference Range
​Marshfield ​Interpretive Report
Interpretation
​See Critical Value List for list of current critical values.
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
88237​ Culture​
88264​ Analyze 20-25 cells​
88280 Additional karyotype, each​ Charge as needed​
88283​ Special Banding​ Charge as needed​
88285​ Additional Cell Count​ Charge as needed​
88291​ Cytogenetics Interp/report​ Charge as needed​
88237  ​ Additional Culture​ Charge as needed​
Synonyms/Keywords
Karyotyping, Karyotype, Bone Marrow, Chromosome Culture, Bone Core Biopsy​
Ordering Applications
Ordering Application Description
​Centricity ​Chrom Cult, Bone Marr
​Cerner ​Chromosome Analysis, Bone Marrow
​COM ​Chrom Cult-Bone Marrow
If the ordering application you are looking for is not listed, contact your local laboratory for assistance.
Specimen Requirements
Fasting Required Specimen Type Preferred Container/Tube Acceptable Container/Tube Specimen Volume Specimen Minimum Volume
Pediatric Minimum Volume
No​ ​Bone Marrow Sodium-heparin Green Top Tube(GTT) ​ 3.0 mL  ​ 1.0 mL​ 1.0 mL​
Collection Processing
Invert the tube several times to assure that no clotting takes place.
 
If the patient has 10% or more circulating blasts, also send a peripheral blood specimen (green top tube -sodium heparin) to Cytogenetics. Notify Cytogenetics (800-222-5835, ext. 16388) when specimen is collected.
Include results of most recent hemogram (CBC and differential), pertinent clinical information and appropriate ICD-10 code(s).
 
Bone core biopsy is acceptable, collect in sterile media such as RPMI or Hanks.​
 
No contingent/ hold orders will be accepted Fridays or Saturdays due to loss of specimen integrity.
Contingent/ hold orders must be resolved by the client by 1500 Friday.
If notification is not received, chromosome analysis will be performed and charged. Contact the Cytogenetics Department at 715-221-6388.
Specimen Stability Information
Specimen Type Temperature Time
Bone Marrow​ Room Temperature  Overnight​
Refrigerate ​ If delay is longer than 24 hours​
Rejection Criteria
Frozen
Interference
If collected in tubes other than sodium heparin,(i.e. EDTA, lithium heparin)the growth and quality of the culture can be affected.​
Useful For
Identifying chromosome anomalies in patients with possible hematologic neoplasms.  Information gained from this study may aid in determining diagnosis and prognosis as well as monitoring the patient's response to therapy.  ​
Reference Range Information
Performing Location Reference Range
​Marshfield ​Interpretive Report
Interpretation
​See Critical Value List for list of current critical values.
For more information visit:
Performing Laboratory Information
Performing Location Day(s) Test Performed Analytical Time Methodology/Instrumentation
Marshfield​ Monday - Saturday​ 2 weeks​ Manual​
For billing questions, see Contacts
Outreach CPTs
CPT Modifier
(if needed)
Quantity Description Comments
88237​ Culture​
88264​ Analyze 20-25 cells​
88280 Additional karyotype, each​ Charge as needed​
88283​ Special Banding​ Charge as needed​
88285​ Additional Cell Count​ Charge as needed​
88291​ Cytogenetics Interp/report​ Charge as needed​
88237  ​ Additional Culture​ Charge as needed​
For most current information refer to the Marshfield Laboratory online reference manual.